Cardiotrophin-1 as a new metabolic biomarker in women with PCOS

Abstract

The objective of this study was to investigate cardiotrophin-1 (CT-1) levels as a new metabolic biomarker in women with polycystic ovary syndrome (PCOS). One hundred consecutive women with PCOS were divided into two groups according to presence of metabolic syndrome as MetS+ and MetS−. Clinical, hormonal and metabolic parameters in addition to CT-1 levels were compared between the groups. Correlation analyses were performed between CT-1 and clinical and metabolic parameters in women with PCOS. One hundred PCOS subjects were enrolled in the study, of which 29 subjects were diagnosed with metabolic syndrome. WHR, systolic and diastolic blood pressures, triglyceride, total cholesterol, HOMA-IR, FAI, FGS and CT-1 levels were significantly higher in the MetS+ group compared with the MetS− group. HDL cholesterol was significantly higher in the MetS− group than the MetS+ one. CT-1 levels were found to be positively correlated with diastolic blood pressure, TG levels and FGS. Cardiotrophin-1 may be a promising new metabolic biomarker in women with PCOS. CT-1 may be beneficial for estimating the risk of long-term adverse health consequences and establishing early intervention and preventation strategies.

Chinese abstract

这项研究的目的是为了研究在多囊卵巢综合征(PCOS)患者中, 心脏营养素-1（CT-1）水平作为一种新的代谢标志物。一百名PCOS患者, 根据有无代谢综合征划分为两组, 分别为MetS+ 和MetS-两组。分别比较两组的临床表现、激素、代谢参数和CT-1的水平。对PCOS患者的CT-1与临床表现和代谢参数进行相关性分析。研究涉及100位PCOS患者, 其中29名受试者诊断为代谢综合征。MetS+组与MetS-组相比, WHR、收缩压和舒张压、甘油三酯、总胆固醇、HOMA-IR、FAI、FGS和CT-1的水平指标明显增高。MetS-组与MetS+组相比, 高密度脂蛋白胆固醇显著增加。CT-1的水平与舒张压、TG水平和FGS成正相关。心脏营养素-1有希望成为PCOS患者新的代谢标志物。CT-1可能有助于评估长期不健康生活的发病率, 并且有助于建立早期干预和预防策略。

Keywords:

• Polycystic ovary syndrome
• cardiotrophin-1
• metabolic syndrome
• metabolic biomarker
• cardiometabolic risk

Disclosure statement

No potential conflict of interest was reported by the authors.