Abstract
This prospective study had the objective to compare anti-Müllerian hormone (AMH) serum levels among women with endometriomas and those with other benign ovarian cysts and verify a possible correlation between the AMH post-operative decline and the achievement of pregnancy. The study included 57 women undergoing laparoscopic surgery. Serum levels of AMH were measured preoperatively and at 6 and 12 months postoperatively. AMH serum levels decreased in both endometriomas and other benign cysts, but significant recovery was reported only in endometriomas (p = .029). Through an interview, information on reproductive outcome was obtained. The secondary endpoint was to identify other predictors of spontaneous pregnancy onset. After surgery 27 women attempted to conceive. At 18-months follow-up, 12 of them got pregnant, with a live birth of 37%. We did not record statistically significant differences in reproductive outcome between women with AMH serum levels lower and higher than 1.1 ng/ml (41.7 and 53.3% respectively). There was no statistically significant difference in AMH serum levels between pregnant and non-pregnant women, neither before nor after surgery. AMH did not appear to have a predictive role on reproductive outcome.
Chinese abstract
这项前瞻性研究的目的是比较子宫内膜异位症和其他良性卵巢囊肿患者的血清抗苗勒激素(AMH)水平, 并验证术后AMH下降情况和妊娠之间的可能相关性。该研究纳入了57名腹腔镜手术女性。 分别测定术前和术后6个月和12个月的血清AMH水平。子宫内膜异位症和其他良性囊肿体内的血清AMH水平均降低, 但子宫内膜异位症患者可明显恢复(P=.029)。通过面谈得到妊娠结局信息。次要终点是确定自发妊娠的其他预测因子。术后27名女性有妊娠需求。在随访的18个月中, 12人怀孕, 活产率为37%。我们并没有发现血清抗苗勒管水平低于或高于1.1ng/ml(分别是41.7% 和53.3%)女性的妊娠结局在统计学上有所不同。无论是手术前还是手术后, 孕妇和非孕妇之间的AMH血清水平均无统计学差异。 AMH似乎对生殖结果没有预测作用。
Disclosure statement
No potential conflict of interest was reported by the authors.