Systematic review and meta-analysis of Spanish studies regarding the association between maternal 25-hydroxyvitamin D levels and perinatal outcomes

Abstract

Objective: This systematic review and meta-analysis of Spanish studies assessed the association of maternal 25-hydroxyvitamin D [25(OH)D] levels on perinatal outcomes.

Methods: PubMed, Cochrane Library, Embase, Scielo, Scopus, and Web of Science research databases were searched from inception through December 30 2017 using the terms ‘vitamin D’, ‘pregnancy’, and ‘Spain’. Studies that compared first or second half of pregnancy normal 25(OH)D (≥30.0 ng/mL) versus insufficient (20.0–29.9 ng/mL) or deficient (<20.0 ng/mL) circulating levels and perinatal outcomes were systematically extracted. Data are presented as pooled odds ratios and their 95% confidence intervals (CIs) for categorical variables or mean differences and CIs for continuous variables. Risk of bias was evaluated with the Newcastle–Ottawa Scale.

Results: Five cohort studies met inclusion criteria. The risk of gestational diabetes mellitus, preeclampsia, preterm birth, and small-for-gestational-age infants, and birthweight was not influenced by first half of pregnancy maternal 25(OH)D levels. In addition, second half of pregnancy 25(OH) levels did not affect birthweight.

Conclusion: Maternal 25(OH)D levels during pregnancy did not affect studied perinatal outcomes and birthweight.

摘要

目的：通过对西班牙研究的系统综述和荟萃分析评估母体25-羟基维生素D [25（OH）D]水平与围产期结局的关系。

方法：使用术语“维生素D”, “妊娠”和“西班牙”在PubMed, Cochrane图书馆, Embase, Scielo, Scopus和Web of Science研究数据库检索2017年12月30日后的文献。系统提取了在妊娠期前半期或后半期正常25（OH）D循环水平（≥30.0ng/ mL）与不足（20.0-29.9ng / mL）或缺乏（<20.0ng / mL）对围产期妊娠结局影响的研究。数据表示为合并比值比, 其分类变量的95％置信区间（CI）或连续变量的均值差异和置信区间。使用Newcastle–Ottawa量表评估偏倚风险。

结果：五项队列研究均符合纳入标准。妊娠期糖尿病, 先兆子痫, 早产, 小于胎龄儿和出生体重的风险不受产妇妊娠前半期25（OH）D水平的影响。 此外, 妊娠后半期25（OH）水平不影响出生体重。

结论：妊娠期母体25（OH）D水平不影响围产期结局和出生体重。

Keywords:

• Preeclampsia
• gestational diabetes mellitus
• preterm birth
• small-for-gestational-age
• vitamin D
• 25-hydroxyvitamin D
• birthweight

Acknowledgments

The authors would like to thank Dr. A.M. Moreno-Fuentes for providing complementary information regarding the content of her doctoral thesis.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research did not receive any specific grant or was funded by any commercial or nonprofit organization or public agency.