Acute pancreatitis secondary to oral contraceptive-induced hypertriglyceridemia: a case report

Abstract

Hypertriglyceridemia is the third most common cause of acute pancreatitis. Among the causes that lead to secondary hypertriglyceridemia, the use of contraceptive agents is the main reason to be assessed in young women. We report a case of a 31-year-old woman who had suffered two acute pancreatitis episodes secondary to hypertriglyceridemia. In the investigation, the previous medical team indicated a genetic screening before ruling out all secondary causes. LPL, apo CII and apo AV genes were negative for mutations. In the first appointment with us, the patient reported the use of a contraceptive agent for about 2 years. She was instructed to discontinue the drug. After one year of follow-up, her serum triglycerides are within the normal range and a copper intrauterine device was the method chosen by the patient for contraception.

摘要

高甘油三酯血症是引起急性胰腺炎的第三大常见病因。而使用避孕药是导致年轻女性继发高甘油三酯血症的主要原因。本例病例报道如下：女性, 31岁, 出现两次继发于高甘油三酯血症的急性胰腺炎发作。在调查中, 先前的医疗小组在排除所有继发原因之前对患者进行了基因筛查, 其中LPL、apo CII和apo AV基因对突变呈阴性。患者自述已服用避孕药约2年。在指导患者停止服药随访一年后, 患者的血清甘油三酯水平降至正常范围内, 而且含铜宫内节育器是这类服用避孕药患者可选择的避孕方法。

Keywords:

• Contraceptive agents
• hypertriglyceridemia
• pancreatitis
• ethinyl estradiol

Disclosure statement

No potential conflict of interest was reported by the authors.