Comparison Of Cimicifuga foetida extract and different hormone therapies regarding in causing breast pain in early postmenopausal women

Abstract

This study aimed to compare the influence between Cimicifuga foetida extract and different hormone therapies on breast pain in early postmenopausal women. A prospective, randomized, controlled clinical trial was conducted among 96 early postmenopausal women. Participants were randomly assigned to three groups: group A received 1 mg/day estradiol valerate plus 4 mg/day medroxyprogesterone acetate on days 19–30; group B received 1 mg/day estradiol valerate plus 100 mg/day micronized progesterone on days 19–30; group C received C. foetida extract, 1talet (contains 33.3 mg extract), t.i.d. Breast pain diary and numerical rating scale was used to access the breast pain. For 6 months’ treatment, the total incidence of breast pain in group A and B was significantly higher than that in group C (p < .05). The duration (day) of breast pain in each month decreased over time in group A and B while it was continuously low and without significant change in group C (p > .05). The intensity of breast pain was mild in most participants and did not differ among three groups (p > .05). During treatment of early postmenopausal women with C. foetida extract for 6 months, the incidence and duration of breast pain were lower than upon treatment with E2 plus cyclic MPA or m-P and did not change over time.

本研究的目的是比较黑升麻提取物与不同激素疗法对绝经早期女性乳房疼痛的影响。一项纳入了96名绝经早期女性的前瞻性随机对照临床研究。受试者随机分为3组：A组给予1mg/d 戊酸雌二醇, 第19-30天加上4mg/d 醋酸甲羟孕酮（MPA）；B组给予1mg/d 戊酸雌二醇, 第19-30天加上100mg/d 微粒化黄体酮（m-P）；C组给予黑升麻提取物, 1片（包含33.3mg黑升麻提取物）, 一天3次。乳房疼痛日记和数值评定量表用于评估乳房疼痛。6个月的治疗后, A组和B组乳房疼痛的总发生率明显高于C组（p＜0.05）。A组和B组每月乳房疼痛持续时间（天）随着时间在减少, 但C组每月乳房疼痛持续时间一直少, 没有明显改变（p>0.05）。大多数受试者乳房疼痛强度是中度的, 并且3组中没有差异（p>0.05）。C组绝经早期女性黑升麻提取物治疗6个月期间, 乳房疼痛的发生率和持续时间低于给予E2加周期MPA或周期m-P, 并且随着时间没有改变。

Keywords:

• Early menopause
• breast pain
• Cimicifuga foetida
• menopausal hormone therapy

Disclosure statement

No potential conflict of interest was reported by the authors.