Effect of vitamin D deficiency on the 75 g oral glucose tolerance test screening and insulin resistance

Abstract

Gestational diabetes mellitus (GDM), is the most common medical complications of pregnancy. This study aimed to clarify the effect of second-trimester vitamin D deficiency on the 75 g oral glucose tolerance test (OGTT) screening and insulin resistance. A total of 120 pregnant women with a singleton pregnancy at a gestational age of 26–28 weeks were analyzed. Participants were divided into two groups according to 25-hydroxyvitamin D levels; vitamin D deficiency, and control groups. For GDM scan, 75 g OGTT was preferred. GDM prevalence was 17.5% in vitamin D deficiency group and 13.75% in control group, there is no significant difference in GDM prevalence (p = 0.149). Fasting plasma glucose and 1-h plasma glucose levels were significantly higher in the vitamin D deficiency group than in the control group (p < .001 and p < .001, respectively). No significant differences were observed between 2-hour plasma glucose levels (p = .266). The HOMA-IR level was significantly higher in the vitamin D deficiency group than in the control group (p < .001). The findings of the present study suggested that vitamin D deficiency in the second trimester was inversely correlated with fasting and 1-h plasma glucose after 75 g glucose challenge test; also, low 25 OHD₃ levels were associated with insulin resistance.

摘要：

妊娠期糖尿病 (GDM) 是妊娠期最常见的医学并发症。本研究旨在阐明孕中期维生素D缺乏对75g口服葡萄糖耐量试验 (OGTT) 筛查和胰岛素抵抗的影响。分析了总共120名孕龄为26-28周的单胎妊娠的孕妇。根据25-羟基维生素D水平将参与者分为两组：维生素D缺乏组和对照组。对于GDM扫描, 优选75g OGTT。维生素D缺乏组的GDM患病率为17.5%, 对照组为13.75%, GDM患病率无显著性差异 (p = 0.149)。维生素D缺乏组的空腹血糖和1-h血浆葡萄糖水平明显高于对照组 (分别为p< 0.001 和p <0.001)。观察两小时血浆葡萄糖水平之间无显著差异 (p = 0.266)。维生素D缺乏组的HOMA-IR水平明显高于对照组 (p < 0.001)。本研究结果提示, 孕中期维生素D缺乏与75g葡萄糖激发试验后空腹及1 h血浆葡萄糖呈负相关;此外, 低水平的25-羟基维生素D水平与胰岛素抵抗有关。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• GDM; gestational diabetes mellitus; 25-hydroxyvitamin D; vitamin D deficiency

Disclosure statement

No potential conflict of interest was reported by the authors.