Evaluation of anti-Müller hormone AMH levels in obese women after sleeve gastrectomy

Abstract

Introduction: The link between obesity epidemic in fertile age and fertility reduction, in relation with BMI increase, has been demonstrated. An inverse proportionality between BMI and anti-Müller hormone (AMH) has been investigated. This hormone is strictly related to ovarian function. It has been demonstrated that it is significantly decreased in obese women.

Scope: The aim of this study was evaluation of AMH levels in 53 obesity women with BMI >35, at 3 and 6 months after laparoscopic sleeve gastrectomy (LSG). Specific evaluation of comorbidities and of gynecological effects of weight loss was also evaluated.

Results: Cohort of 53 women was considered, treated with LSG. A progressive increase of AMH levels after LSG was confirmed, with statistically significant results at followup of 6 months. In these patients, we also observed an improvement in the menstrual cycle and resolution of dysmenorrhea. All considered comorbidities were ameliorated at both followup.

Conclusion: LSG determined a significant increase of AMH level in women, at early followup, with a comprehensive amelioration of gynecological status. Larger cohorts and a better evaluation of ovarian function after LSG will lead to more powerful results of the effect of weight loss on women.

摘要

介绍：育龄期肥胖病和与BMI增加相关的生育率降低之间的关系已经被证明, BMI与AMH的反比例关系已经在研究, AMH确实与卵巢功能相关, 已经证实AMH在肥胖女性中明显降低。

范围：本研究目的是评估53名BMI >35的肥胖女性在腹腔镜下袖状胃减容术（LSG）后3个月、6个月的AMH水平, 并详细的评估并发症以及体重下降对妇科方面的影响。

结果：53名行LSG术的女性, 已确定LSG术后AMH水平上升, 且术后随访6个月AMH升高具有统计学意义。这些患者中, 我们观察到月经周期以及痛经的改善。所有考虑到的并发症在两次随访中均发现有改善。

结论：在早期随访中, LSG术使得女性AMH水平明显升高, 并且妇科症状得到全面改善。更大的队列和更好的评估LSG术后卵巢功能将能够得出体重减轻对女性影响的更有力的结果。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Obesity
• sleeve gastrectomy
• anti-Müller hormone (AMH)
• infertility
• dysmenorrhea

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Acknowledgments

No acknowledgment was required. At the moment of submission, this research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Disclosure statement

All authors declare that they have no conflict of interest.