Ultrasonographically diagnosed dermoid cysts do not influence ovarian stimulation response in an in vitro fertilization cycle

Abstract

To determine if patients with a DC respond similarly to ovarian stimulation when compared to patients without a DC. Infertility patients with a DC that underwent IVF between January 2009 and December 2016 were included. A cystic mass with mixed echogenicity, internal echoes similar to thick bands, fatty-fluid level, or an echogenic tubercle with acoustic shadow (Rokitansky nodule) within two years of the cycle characterized the diagnosis. The z-score compared the standard deviations (SDs) in patients with/without a DC and were compared to a nomogram (expected oocytes minus oocytes obtained divided by the SD), adjusted for age and number of oocytes retrieved, built utilizing cycles from noninfertile female patients. Thirty-nine patients with DC and 7839 patients without DC were identified. The mean number of oocytes (8.6 ± 5.8 vs. 8.5 ± 7.7, p = .43) and MIIs (6.7 ± 4.7 vs. 7.0 ± 6.7, p = .74) retrieved were similar. When cycles with and without a DC were compared to the nomogram (z-score of 0), cycles with a DC presented a z-score for ovarian response of 0.1921 SDs from the mean, and patients without DC presented a z-score of −0.2065 SDs from the mean (similar and less than −1.0). After building a population ‘normal’ response as a template, patients with and without a DC responded similar to COS.

摘要

为了研究DC患者与非DC患者相比对卵巢刺激反应是否相似。研究纳入了2009年1月至2016年12月接受体外受精治疗的患有DC的不孕症女性。在两年的超声影像中反复出现以囊性肿块混合回声、内部回声似厚条带状、脂肪液平、结节回声伴声影 (Rokitansky结节) 为特点的诊断特征。通过z评分比较患有/不患有DC的患者的标准差（SDs）, 并通过列线图（预期的卵母细胞减去实际获得的卵母细胞除以SD）进行比较, 根据年龄和获得的卵母细胞数进行调整, 利用非不孕女性患者构建体外受精周期。确定了39例DC患者和7839例非DC患者。平均卵母细胞数(8.6 ± 5.8 vs. 8.5 ± 7.7, p=.43) 及重新获取的MIIs (6.7 ± 4.7 vs. 7.0 ± 6.7, p=.74) 相似。有或没有DC的体外受精周期的列线图（z值为0）相比时, 患有DC的患者卵巢反应的z值为0.1921 SDs, 无DC的患者卵巢反应的z值为0.2065 SDs（相似并且小于1.0）。在建立一个群体“正常”反应模型后, 患有DC和无DC的患者反应与COS相似。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Ovarian stimulation
• dermoid cyst
• ovarian germ cell tumor
• IVF
• in vitro fertilization

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Funding for this work was not received. This research was performed under the auspices of ‘Càtedra d’Investigació en Obstetrícia I Ginecologia’ of the Department of Obstetrics, Gynaecology and Reproductive Medicine, Hospital Universitario Dexeus, Universitat Autònoma de Barcelona.