Abstract
This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). In total, 41 girls with CPP and 35 age-matched normal control girls were enrolled. Serum values of MKRN3 were measured in both groups. Gonadotropin and estradiol concentrations were evaluated after 6 and 12 months of GnRH agonist (GnRHa) treatment in CPP patients. The MKRN3 concentrations were much lower in the patient group than in the control group (p = .005). Over 1 year of GnRHa treatment in patients, the gonadotropin concentrations were significantly decreased (p < .05), while the MKRN3 concentrations were unchanged (p > .05). MKRN3 levels were inversely correlated to standard deviation (SD) in height (r = −0.46, p = .000), SD in weight (r = −0.32, p = .005), Tanner stage (r = −0.41, p = .000), and bone age (r = −0.46, p = .000). Based on ROC analysis, the area under curve was 0.758 for MKRN3, with 82.9% sensitivity and 68.5% specificity. The measurement of serum MKRN3 level may provide some help for CPP prediction, but relatively various values need further validation
摘要
本研究检测了血清MKRN3水平, 并探讨了其对女童性早熟(CPP)的诊断价值。共纳入41例CPP女童和35例年龄匹配的正常对照组女童。测定两组患者血清MKRN3水平。在CPP患者接受GnRH激动剂 (GnRHa) 治疗6个月和12个月后, 评估促性腺激素和雌二醇的浓度。CPP组MKRN3浓度明显低于对照组(p = .005)。对于超过1年的GnRHa治疗患者,促性腺激素浓度明显下降(p < . 05), 而MKRN3浓度保持不变(p > . 05)。MKRN3水平与身高(r = 0.46, p=.000)、体重(r = 0.32, p=.005)、唐纳分期(r = 0.41, p=.000)和骨龄(r = 0.46, p=.000)的标准差呈负相关。根据ROC分析, MKRN3的曲线下面积为0.758, 敏感性为82.9%, 特异性为68.5%。测量血清MKRN3水平可能为CPP预测提供一定的帮助, 但尚需要进一步验证。
The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
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Disclosure statement
No potential conflict of interest was reported by the authors.