Androgen profile in young females with insulin resistance; the importance of 17-Hydroxyprogesterone

Abstract

Considerable researches on sex steroids and insulin action have suggested a mutual interaction between hyperandrogenemia and insulin resistance (IR). The objective of present study was to evaluate the androgens levels in young females with emphasis on the association of 17OHP with IR. Serum concentrations of glucose, insulin, and androgens in 80 young females were measured by standard routine procedures. Total testosterone (TT), dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEAS), androstenedione (ASD), and 17-hydroxyprogesterone (17OHP) levels were higher in patients with IR compared to healthy controls (p < .05). 17OHP was associated with IR and other androgens tested in young females. According to the results, androgen excess was associated with IR in young females and TT appeared to be independent predictor of IR in these patients. These data may suggest that simultaneous quantification of an androgen profile including at least TT, DHT, and 17OHP can present useful clinical information for assessment of androgen excess.

摘要

大量关于性类固醇激素和胰岛素作用的研究表明高雄激素血症与胰岛素抵抗（IR）相互作用。本研究的目的是评估年轻女性的雄激素水平, 重点是17OHP与IR的关联。通过标准常规程序测定80例年轻女性的血糖、胰岛素和雄激素血清水平。与健康对照组相比具有IR的患者总睾酮(TT)、二氢睾酮(DHT）、硫酸脱氢表雄酮(DHEAS)、雄烯二酮(ASD)以及17-羟孕酮（17OHP)水平更高(p＜.05)。年轻女性17OHP与IR及其他雄激素检测相关。结果显示年轻女性中过多的雄激素与IR相关, TT可能作为IR的独立预测因子。这些提示通过同时定量雄激素分布至少包括TT,DHT,17OH可能可以提供有效的临床信息从而评估雄激素过多。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Androgen
• testosterone
• dehydroepiandrosterone
• androstenedione
• 17-hydroxyprogesterone
• insulin resistance

Disclosure statement

The authors report no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.