Abstract
This study determined the effect of exogenous soluble receptor for advanced glycation end products (sRAGE) on the pro-inflammatory activities that occur during polycystic ovary syndrome (PCOS) in human follicular cells and explored a potential mechanism for preventing the development of inflammation. Follicular fluid was allocated into one of three treatment groups (0, 0.6, and 1.2 μg mL−1 of sRAGE). Collectively, these results indicate that exogenous sRAGE supplementation alleviates inflammation in ovarian follicular granulosa cells by regulating p-ERK and AP-1 signaling.
摘要
本研究测定了外源性晚期糖基化终产物可溶性受体(sRAGE)对多囊卵巢综合征(PCOS)患者卵泡细胞促炎活性的影响, 并探讨其可能的抗炎机制。卵泡液被分为三组(0, 0.6, and 1.2 μg mL-1 of sRAGE)。总之, 这些结果表明, 外源性sRAGE通过调节p-ERK和AP-1信号通路, 减轻了卵泡颗粒细胞的炎症反应。
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Disclosure statement
The authors declare that they have no conflict of interests.