Neonatal outcome in pregnancy hypotiroidee women

Abstract

To evaluate the impact that hypothyroidism may have on the course of pregnancy and on neonatal outcome. This cross-sectional study consisting of 160 pregnant women (60 with hypothyroidism and 100 as control) who had been hospitalized at the Obstetrics and Gynecology of the University of Siena. The obstetric visit, the collection of anamnestic data and serum concentrations of TSH, FT4 and AbTPO were performed for each woman. Stratification of the population into two groups based on the BMI showed that there is an average difference of −0.88 before pregnancy BMI between healthy women and hypothyroid women. Moreover, with regard to the obstetric history, 8.7 times higher risk of abortion was found in hypothyroid women. About the current pregnancy in hypothyroid women, slight fetal growth delay, increased risk of premature rupture of membranes (PROM), and a higher risk of developing hypertension and gestational diabetes had been found. The importance of a more detailed anamnesis should be evaluated with greater attention at the beginning of pregnancy. This, in order to avoid the risks related to a hypothyroidism condition during pregnancy and to establish an early therapeutic treatment appropriate to the metabolic demands of each patient.

摘要

评估甲状腺功能减退对妊娠过程和新生儿结局的影响。这项横断面研究包括160名在Siena大学妇产科住院的孕妇（60名甲状腺功能减退患者, 100名对照患者）。对每位产妇进行产科随访、随访数据搜集以及TSH、FT4和AbTPO的血清浓度。根据体重指数将人群分为两组, 结果显示健康女性和甲状腺功能减退的女性在怀孕前的平均BMI的差异为-0.88。此外, 在产科既往史方面, 甲状腺功能减退女性流产风险较正常组高8.7倍。目前甲状腺功能减退的孕妇, 已出现胎儿生长延迟、胎膜早破（PROM)的风险增加, 以及更高的风险发展为高血压和妊娠期糖尿病。在妊娠初期, 应更注重评估既往史的更多细节。这样做是为了避免与妊娠期间甲状腺功能减退的有关风险, 并建立适合患者的代谢需求的早期治疗的个体化方案。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Pregnancy
• hypotiroidee women
• neonatal outcome
• miscarriage
• gestational diabetes
• hypertension

Disclosure statement

No potential conflict of interest was reported by the authors.