Galectin-3 is a potential biomarker to insulin resistance and obesity in women with polycystic ovary syndrome

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder that affects women in reproductive age. This study aimed to evaluate Gal-3 levels and its role on metabolic parameters in women with PCOS. Gal-3 was measured in 44 PCOS and 25 women recruited as control group for the case-control study. Gal-3 levels were similar between PCOS and control groups (p > 0.05), but showed a positive correlation with glucose levels in the oral glucose tolerance test (OGTT) (r = 0.403, p = 0.037), body mass index (BMI) (r = 0.469, p = 0.027), insulin levels (r = 0.453, p = 0.030) and HOMA-IR (r = 0.738, p = 0.037) in PCOS group. The data suggest that Gal-3 plays a role in the pathophysiology of the insulin resistance and obesity in PCOS group.

摘要

多囊卵巢综合征（PCOS）是影响育龄期女性最常见的内分泌和代谢疾病。本研究旨在评估PCOS患者的Gal-3水平及其对代谢参数的影响。这是一个病例对照研究, 检测了44例PCOS患者以及25例对照组患者的Gal-3水平。两组人群的Gal-3水平相似（P>0.05）, 但是在PCOS组, Gal-3水平与OGTT试验中的血糖水平（r=0.403, p=0.037）, BMI（r=0.469, p=0.027）, 胰岛素水平（r=0.453, p=0.030）以及HOMA-IR（r=0.738, p=0.037）呈正相关。结果提示我们, Gal-3水平在PCOS患者胰岛素抵抗和肥胖的病理生理中发挥作用。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Polycystic ovary syndrome
• galectin-3
• obesity
• insulin resistance
• glucose

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil) by the financial support. FMR and KBG are grateful to CNPq Research Fellowship (PQ).