Abstract
Background
This study aimed at determining the effects of coenzyme Q10 (CoQ10) supplementation on the inflammatory and endothelial dysfunction indices among overweight and obese women with polycystic ovary syndrome (PCOS).
Methods
This randomized double-blind, placebo-controlled clinical trial was performed among overweight and obese women diagnosed with PCOS. Forty three PCOS women were randomly assigned to two groups: one group received 200 mg CoQ10 capsules per day (n = 22) and the other received placebo (n = 21) for 8 weeks. Biomarkers of inflammation and endothelial dysfunction including high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin were measured and compared before and after the intervention.
Results
At the end of study, compared with pldacebo, CoQ10 supplementation resulted in significant decreases in serum levels of TNF-α (p = 0.009), hs-CRP and IL-6 (p = 0.001, p = 0.007, respectively). In addition, supplementation with CoQ10 resulted in a significant reduction in serum VCAM-1 (p = .002) and E-selectin (p = .006) compared with the control group. There were no significant differences for serum ICAM-1.
Conclusions
The present study showed that CoQ10 supplementation for 8 weeks had a beneficial effect on inflammatory and endothelial dysfunction markers in overweight and obese patients with PCOS.
摘要
背景:这项研究旨在确定补充辅酶Q10(CoQ10)对超重/肥胖多囊卵巢综合征(PCOS)女性的炎症和内皮功能障碍指标的影响。
方法:这项随机双盲、安慰剂对照的临床试验在诊断为PCOS的超重和肥胖妇女中进行。43名PCOS女性被随机分为两组:一组每天接受200 mg CoQ10胶囊(n = 22), 另一组接受安慰剂(n = 21), 持续8周。干预前后测量炎症和内皮功能障碍的生物标志物, 包括高敏C反应蛋白(hs-CRP), 肿瘤坏死因子-α(TNF-α), 白介素-6(IL-6), 细胞间粘附分子-1(VCAM-1)和E-选择素。
结果:在研究结束时, 与安慰剂组相比, 补充辅酶Q10能显著降低血清TNF-α(p = 0.009)、hs-CRP(p = 0.001)、IL-6 (p = 0.007)的水平。除此之外, 补充辅酶 Q10可显著降低血清 VCAM-1(p = 0.002) 和E-选择素(p = 0.006)的水平, 血清CAM-1水平无显著差异。
结论: 本研究表明, 补充辅酶 Q10 八周, 可以显著降低超重和肥胖 PCOS 患者的炎症和内皮功能障碍标志物水平。
Acknowledgment
The present study was based on MSc thesis in nutrition and supported by a grant from Nutrition Research Center, and Student Research Committee, at the Research Vice Chancellor, Tabriz University of Medical Sciences, Tabriz, Iran. (Grant number 5/D/478865).
Disclosure statement
No potential conflict of interest was reported by the author(s).