Effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials

Abstract

Objective

The purpose of this meta-analysis was to evaluate the effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome (PCOS).

Methods

We performed a literature search of databases and identified randomized controlled trials (RCTs) published prior to December 2019. A meta-analysis was conducted using RevMan 5.3 and Stata 12.0 software. We compared the effects of vitamin D supplementation alone to the administration of placebos on metabolic parameters of PCOS women with vitamin D deficiency.

Results

Ten articles of RCTs were included and analyzed in this meta-analysis, which included a total of 520 PCOS women. Our meta-analysis results showed no significant effects of vitamin D supplementation on BMI (p = .43), systolic blood pressure (p = .05), diastolic blood pressure (p = .87), fasting insulin concentration (p = .86), HOMA-IR (p = .47), HDL-C (p = .76), LDL-C (p = .23) and triglyceride (p = .77). Both low dose vitamin D supplementation (<4000 IU/day) and high dose vitamin D supplementation (≥4000 IU/day) were found to significantly decreased the fasting glucose concentration (p = .01, p = .001, respectively). Vitamin D supplementation significantly decreased total cholesterol concentration (p = .03).

Conclusions

The results of this meta-analysis suggested that vitamin D supplementation decreases fasting glucose concentration and total cholesterol concentration in PCOS women with vitamin D deficiency.

摘要

目的：这项meta分析的目的是评估维生素D补充剂对多囊卵巢综合征（PCOS）女性代谢指标的影响。

方法：我们对数据库进行了文献搜索, 确定了2019年12月之前发表的随机对照试验（RCT）。采用RevMan 5.3和Stata 12.0软件进行meta分析。我们比较了单独维生素D补充剂和服用安慰剂对患有维生素D缺乏的多囊卵巢综合征女性代谢指标的影响。

结果：这项meta分析纳入并分析了10篇随机对照试验, 共包括520名PCOS女性。我们的meta分析结果显示维生素D补充剂对BMI（p=0.43）、收缩压（p=0.05）、舒张压（p=0.87）、空腹胰岛素浓度（p=0.86）、HOMA-IR（p=0.47）、HDL-C（p=0.76）、LDL-C（p=0.23）和甘油三酯（p=0.77）没有显著影响。低剂量维生素D补充剂（<4000IU/d）和大剂量维生素D补充剂（≥4000IU/d）均可显著降低空腹血糖水平（分别p=0.01, p=0.001）。补充维生素D显著降低总胆固醇浓度（p=0.03）。

结论：这项meta分析的结果表明, 维生素D补充剂降低了患有维生素D缺乏的多囊卵巢综合征女性的空腹血糖水平和总胆固醇浓度。

Keywords:

• Vitamin D supplementation
• metabolic parameters
• polycystic ovary syndrome
• randomized controlled trials
• meta-analysis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research was funded by Natural Science Basic Research Program of Shaanxi (Program No.2019JM-569), and by Institutional Foundation of the First Affiliated Hospital of Xi’an Jiaotong University (Program No.2019ZYTS-03).