Serum kisspeptin levels correlated with anti-mullerian hormone levels in women with and without polycystic ovarian syndrome

Abstract

Objective: To determine serum kisspeptin and anti-mullerian hormone (AMH) levels in women with and without polycystic ovary syndrome (PCOS).

Materials and methods

This was a prospective, cross-sectional, comparative study that included 70 women with PCOS and 58 non PCOS controls. PCOS patients were diagnosed according to the Rotterdam criteria. Age, body mass index (BMI), number of menstrual cycles per year, and the Ferriman-Gallwey Score were determined for each woman. Serum levels of kisspeptin, follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), estradiol, total testosterone, dehydroepiandrosterone sulfate (DHEA-S), AMH, fasting glucose and insulin were determined.

Results

Women with PCOS were younger (p < .001), with higher BMI (p = .027) and glucose values (p < .001); while displaying less number of menstrual cycles per year (p < .001). Although serum kisspeptin levels were similar in both groups, age was negatively (r= −0.33, p = .00018) and serum AMH levels were positively correlated (r = 0.25, p = .0039) with the serum kisspeptin levels in women with the PCOS. After adjusting for age, serum kisspeptin levels were comparable in both groups (p > .05). Serum LH, AMH, DHEA-S and total testosterone glucose, insulin levels and HOMA-IR values were significantly higher in women with PCOS as compared to controls (all p < .05).

Conclusions

Serum kisspeptin levels were similar in women with and without PCOS but positively correlated with AMH serum levels in PCOS women.

摘要

目的：测定多囊卵巢综合征（PCOS）患者和非PCOS患者血清神经激肽B和抗苗勒管激素（AMH）水平。材料和方法：这是一项前瞻性、横断面的比较研究, 包括70名多囊卵巢综合征患者和58名非多囊卵巢综合征的女性对照。PCOS患者的诊断标准依据鹿特丹标准。测定每位女性的年龄、身体质量指数（BMI）、每年的月经次数以及FerrimanGallwey评分。测定血清神经激肽B、卵泡刺激素（FSH）、黄体生成素（LH）、促甲状腺激素（TSH）、雌二醇、总睾酮、硫酸脱氢表雄酮（DHEA-S）、AMH、空腹血糖和胰岛素水平。结果：多囊卵巢综合征的患者更年轻（p<0.001）, BMI（p=0.027）和血糖值（p<0.001）；同时表现每年月经次数减少。尽管两组患者的血清神经激肽B水平相似, 但PCOS患者的年龄与血清神经激肽B水平呈负相关（r=0.33, p=0.00018）, 血清AMH水平与PCOS患者的血清神经激肽B水平呈正相关（r = 0.25, p = 0.0039）。校正年龄后, 两组的血清神经激肽B的水平相似(p >0 .05)。PCOS患者的血清LH、AMH、DHEA-S、总睾酮、葡萄糖、胰岛素水平和HOMA-IR值均显著高于对照组（p <0 .05）。结论：有无PCOS患者的血清中神经激肽B水平相似, 但PCOS患者中AMH水平与神经激肽B水平呈正相关。

Keywords:

• Kisspeptin
• anti-mullerian hormone
• polycystic ovary syndrome
• HOMA-IR Insulin

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data statement

The data of the study is uploaded to the Mendeley Data System.

Ayşegül Mut designed and managed the study and wrote the article.

C.Tamer Erel was the mentor and conductor of the study. He contributed to the writing of the article.

Deniz Inan performed the statistical analysis of the study.

Aysegul Mut and Yahya Özgün Öner evaluated the patients, collected blood samples and performed the data collection.