Umbilical cord N-terminal procollagen of type l collagen (P1NP) and beta C-terminal telopeptide (βCTX) levels in term pregnancies with vitamin D deficiency

Abstract

Aims

The aim of the present study was to evaluate umbilical cord N-terminal procollagen of type l collagen (P1NP) and beta C-terminal telopeptide (βCTX) levels in term pregnancies with vitamin D deficiency.

Materials and methods

Ninety-two pregnant women between 19 and 35-years-old who delivered at term gestational age were included in the study and divided into deficient (n = 32), insufficient (n = 30), and normal (control) vitamin D levels (n = 30).

Results

Maternal demographic characteristics and biochemical parameters were similar among groups. The mean umbilical cord P1NP level was 221.4 (211.7–231.0, 95%CI) pg/mL in the vitamin D deficiency group, 282.5 (271.2–293.8, 95%CI) pg/mL in the vitamin D insufficiency group, and 280.9 (270.9–290.8, 95%CI) pg/mL in the control group and significantly lower in vitamin D deficiency group than others (p < .001). Umbilical cord P1NP level was similar in the vitamin D insufficiency group and control group (p = .971). The mean umbilical cord βCTX level was 5530, 9 (5511.5–5550.3, 95%CI) pg/mL in the vitamin D deficiency group, 5516.3 (5498.4–5534.2, 95%CI) pg/mL in the vitamin D insufficiency group, and 5510 (5491.4–5528.5, 95%CI) pg/mL in the control group, which was statistically similar among the groups (p = .251).

Conclusion

Our results indicated that vitamin D deficiency during pregnancy affects fetal bone osteoblast activity.

摘要

目的:本研究的目的是评估维生素D缺乏的足月妊娠的脐带l型前胶原氨基端肽(P1NP)和B-胶原降解产物(bCTX)水平。

材料和方法:92名19-35岁足月分娩的孕妇被纳入研究, 并被分为维生素D水平缺乏(32名)、不足(30名)和正常(对照)(30名)。

结果:各组产妇人口学特征和生化参数相似。平均脐带P1NP水平在维生素D缺乏组为221.4(211.7–231.0, 95%置信区间)皮克/毫升, 在维生素D缺乏组为282.5(271.2–293.8, 95%置信区间)皮克/毫升, 在对照组为280.9(270.9–290.8, 95%置信区间)皮克/毫升, 在维生素D缺乏组明显低于其他组(p < .001)。维生素D缺乏组和对照组的脐带P1NP水平相似(p .971)。平均脐带bCTX水平在维生素D缺乏组为5530, 9(5511.5–5550.3, 95%置信区间)皮克/毫升, 在维生素D缺乏组为5516.3(5498.4–5534.2, 95%置信区间)皮克/毫升, 在对照组为5510(5491.4–5528.5, 95%置信区间)皮克/毫升, 两组之间有统计学上的相似性(p .251)。

结论:我们的结果表明, 孕期维生素D缺乏影响胎儿成骨细胞的活性。

Keywords:

• Vitamin D deficiency
• C-terminal telopeptide
• βCTX
• N-terminal procollagen of type l collagen (P1NP)

Disclosure statement

No potential conflict of interest was reported by the author(s).