Abstract
Aims
To investigate the correlation between hypertriglyceridemic waist circumference (HTWC) phenotype and gestational diabetes mellitus (GDM).
Methods
A total of 1083 patients with gestational age ≤8 weeks were divided into four groups: normal triglyceride and waist circumference group (group A, n = 575), simple abdominal obesity group (group B, n = 317), simple high triglyceride group (group C, n = 125), and HTWC group (group D, n = 66). General information and serum biochemical indicators were measured and recorded. Analysis of variance (ANOVA) and logistic regression analysis were used to evaluate the relationship between HTWC with GDM.
Results
The prevalence of GDM in the HTWC group was significantly greater than in the other three groups. After adjustment by multivariate logistic regression analysis, the proportion of GDM in the HTWC group was 1.753 times higher than in group A.
Conclusion
These findings suggest that there is a significant correlation between HTWC phenotype and GDM, indicating that the HTWC phenotype could be applied as a simple marker for identifying GDM risk factors.
摘要
目的:探讨高甘油三酯血症腰围(HTWC)表型与妊娠期糖尿病(GDM)的相关性。
方法:1083例孕周≤8周的孕妇分为四组: 正常甘油三酯和正常腰围组(A组, n = 575), 单纯性腹型肥胖组(B组, n = 317), 单纯性高甘油三酯组(C组, n = 125), HTWC组(D组, n = 66)。测量并记录一般信息和血清生化指标。方差分析和logistic回归分析用于评价HTWC与GDM的关系。
结果:HTWC组的GDM患病率明显高于其他三组。经多元logistic回归分析调整后, HTWC组GDM的比例是A组的1.753倍。
结论:这些发现表明HTWC表型和GDM之间存在显著的相关性, 表明HTWC表型可以作为识别GDM危险因素的简单标记。
Disclosure statement
The authors declare no competing interests.
Author contributions
Qiang Lu designed the Project, Conceptualization and Supervision. Tianshu Hua performed the experiments. Xiaojiao Jia, Jiaxin Wang performed the data analyses and wrote the manuscript. Liwei Bai, Tianshu Hua, Zhonghou Han and Qiang Lu helped perform the analysis with constructive discussions.