Progranulin and tumor necrosis factor-alpha in lean polycystic ovary syndrome patients

Abstract

Objective

In this study, levels of progranulin (PGRN) and tumor necrosis factor-alpha (TNF-α) were measured to detect the presence of inflammation in lean polycystic ovary (PCOS) patients.

Methods

40 lean PCOS patients were assessed by Rotterdam criteria. Forty healthy women with regular menstrual cycles and without biochemical and clinical hyperandrogenism were involved in our study. Blood samples were taken from the patient and control groups for the measurement of progranulin (PGRN), tumor necrosis factor-alpha (TNF-α), lipid parameters, glucose, insulin, and other hormones.

Results

Serum PGRN and TNF-α levels were significantly higher in patients with lean PCOS, compared with the control group (p = .037, p = .041). PGRN levels were positively correlated with TNF-α levels in lean PCOS patients.

Conclusion

PGRN is known as a ligand for the TNF-α receptor. PGRN level increase in lean PCOS patients may be due to inhibiting the inflammatory effects of TNF-α. To observe the PGRN and TNF-α connection in obesity, further study is needed in obese PCOS patients and obese control groups.

瘦型多囊卵巢综合征患者的颗粒蛋白前体和肿瘤坏死因子-α 摘要

目的：在本研究中, 检测瘦型多囊卵巢（PCOS）患者的颗粒蛋白前体（progranulin, PGRN）和肿瘤坏死因子-α（TNF-α）水平, 以检测是否存在炎症。

方法：40例多囊卵巢综合征患者均符合鹿特丹标准。40名月经周期正常、无生化和临床高雄激素血症的健康女性参与了我们的研究。从患者和对照组中采集血液样本, 用于测量PGRN、TNF-α、血脂参数、葡萄糖、胰岛素和其他激素。

结果：瘦型PCOS患者的血清PGRN和TNF-α水平显著高于对照组（p=0.037, p=0.041）。瘦型PCOS患者PGRN水平与TNF-α水平呈正相关。

结论：PGRN是TNF-α受体的配体。瘦型PCOS患者PGRN水平升高, 可能是由于抑制TNF-α的炎症作用。为了观察肥胖患者PGRN和TNF-α之间的关系, 需要在肥胖PCOS患者和肥胖对照组中进行进一步研究。

Keywords:

• Polycystic ovary syndrome
• progranulin
• tumor necrosis factor-alpha
• inflammation

Disclosure statement

No potential conflict of interest was reported by the author(s).

ORCID

Andac Uzdogan: https://orcid.org/0000-0003-2950-2680