Abstract
Objectives
We aimed to examine the change in plasma copper (Cu) level and copper transport proteins level before inserting Cu-IUD and after one menstrual cycle and to show the effect of this change on the thiol disulfide balance in women using copper-containing intrauterine device (Cu-IUD).
Method
Thirty-three reproductive women who admitted to the gynecology clinic and inserted Cu-IUD were examined in this study. Thiol-disulfide homeostasis, plasma Cu and ceruloplasmin levels and ceruloplasmin ferroxidase activity were measured using the blood samples collected just before inserting Cu-IUD and after one menstrual cycle.
Results
Plasma copper level (p = 0.006), ceruloplasmin (p < 0.001), Ceruloplasmin Ferroxidase (p = 0.005), thiol disulfide homeostasis parameters; native thiol (NT) (p = 0.004), and total thiol (p = 0.003) levels increased significantly.
Conclusion
After one menstrual cycle in women inserted intrauterine Cu-IUD for contraception, plasma levels of Cu, which is the oxidant molecule, increased significantly. Both plasma ceruloplasmin level and ceruloplasmin ferroxidase activity increased due to elevated Cu levels. This increased oxidant status in the acute period was balanced by the increase in the native thiol level.
摘要
目的
我们旨在检查插入 Cu-IUD 前和一个月经周期后血浆铜 (Cu) 水平和铜转运蛋白水平的变化, 并显示这种变化对使用含铜宫内节育器的女性二硫醇平衡的影响装置(Cu-IUD)。
方法
本研究对 33 名在妇科门诊就诊并置入 Cu-IUD 的生育女性进行了检查。使用插入 Cu-IUD 之前和一个月经周期后采集的血样测量硫醇二硫化物稳态、血浆 Cu 和铜蓝蛋白水平以及铜蓝蛋白氧化亚铁酶活性。
结果
血浆铜水平 (p = 0.006)、铜蓝蛋白 (p < 0.001)、铜蓝蛋白氧化亚铁酶 (p = 0.005)、硫醇二硫化物稳态参数;天然硫醇 (NT) (p = 0.004) 和总硫醇 (p = 0.003) 水平显着增加。
结论
女性在一个月经周期后, 经宫内Cu-IUD避孕后, 血浆中氧化剂分子Cu的水平显著升高。由于铜水平升高, 血浆铜蓝蛋白水平和铜蓝蛋白氧化亚铁酶活性均增加。这种在急性期增加的氧化剂状态被天然硫醇水平的增加所平衡。