Metalloproteolytic receptor shedding…platelets “acting their age”

Abstract

Whilst significant effort has been focused on development of tools and approaches to clinically modulate activation processes that consume platelets, the platelet receptors that initiate activation processes remain untargeted. The modulation of receptor levels is also linked to underlying platelet aging processes which influence normal platelet lifespan and also the functionality and survival of stored platelets that are used in transfusion. In this review, we will focus on platelet adhesion receptors initiating thrombus formation, and discuss how regulation of levels of these receptors impact platelet function and platelet survival.

Keywords:

• Glycoprotein
• metalloproteinase
• platelet
• thrombocytopenia

Declaration of interest

All authors declare no conflicts of interest.

Funding

We received financial support from the National Health and Medical Research Council of Australia and the National Heart Foundation of Australia.

Additional information

Funding

We received financial support from the National Health and Medical Research Council of Australia and the National Heart Foundation of Australia.