Platelet indices in patients with chronic inflammatory arthritis: a systematic review and meta-analysis

Abstract

Correlation between platelet indices and chronic inflammatory arthritis (CIA) remains a moot point today. This meta-analysis aimed to evaluate whether platelet (PLT) count, mean platelet volume (MPV) and platelet distribution width (PDW) associated with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA). A systematic literature search was performed in PubMed, EMBASE, and Web of Science up to August 2019. Pooled standardized mean differences (SMD) and 95% confidence interval (CI) were calculated using a random-effect model. As a result, 34 studies were included, encompassing 17 on RA, 12 on AS, 3 on PsA and 2 on both RA and AS. In these studies, PLT count was significantly higher in RA (SMD = 0.55, 95% CI = 0.36–0.73, P < .001), AS (SMD = 0.53, 95% CI = 0.36–0.70, P < .001) and PsA patients (SMD = 1.29, 95% CI = 0.82–1.77, P < .001) than that in healthy subjects, while MPV and PDW presented nonsignificant differences in these intergroup comparisons (P > .05), and similar results were observed in subgroup analyses. The meta-regression analysis demonstrated that there were strong positive correlations between erythrocyte sedimentation rate and PLT count, and weak correlation trend between the disease activity score and PLT count in both RA and AS subjects without statistically significant difference. The sensitivity analysis indicated that these results were not unduly influenced by any single study. In conclusion, this meta-analysis demonstrated that PLT count was elevated in CIA patients and could be suitable for evaluating the disease activity, whereas MPV and PDW were independent of CIA.

Keywords:

• Ankylosing spondylitis
• mean platelet volume
• Platelet count
• platelet distribution width
• psoriatic arthritis
• rheumatoid arthritis

Author contribution

Zhongwei Zhou and Hongmei Chen contributed to literature search, data extraction and drafted the manuscript. Huixiang Ju and Mingzhong Sun contributed to quality assessment, statistical analysis, and revision of the manuscript. Hao Jin designed the study, and performed data interpretation, revision of the manuscript.

Declaration of interest

The authors declare that they have no conflict of interest.

Supplementary material

Supplemental data for this article can be accessed here.

Additional information

Funding

This study was not funded.