Mouse models of hemostasis

Abstract

Hemostasis is the normal process that produces a blood clot at a site of vascular injury. Mice are widely used to study hemostasis and abnormalities of blood coagulation because their hemostatic system is similar in most respects to that of humans, and their genomes can be easily manipulated to create models of inherited human coagulation disorders. Two of the most widely used techniques for assessing hemostasis in mice are the tail bleeding time (TBT) and saphenous vein bleeding (SVB) models. Here we discuss the use of these methods in the evaluation of hemostasis, and the advantages and limits of using mice as surrogates for studying hemostasis in humans.

Keywords:

• Bleeding
• hemostasis
• mouse models

Additional information

Funding

This work was supported by the American Heart Association [8POST34030076];American Society of Hematology [Bridge Grant];National Heart, Lung, and Blood Institute [HL14025].