On the front line of HIV virological monitoring: barriers and facilitators from a provider perspective in resource-limited settings

Abstract

Scale-up of viral load (VL) monitoring for HIV-infected patients on antiretroviral therapy (ART) is a priority in many resource-limited settings, and ART providers are critical to effective program implementation. We explored provider-perceived barriers and facilitators of VL monitoring. We interviewed all providers (n = 17) engaged in a public health evaluation of dried blood spots for VL monitoring at five ART clinics in Malawi. All ART clinics were housed within district hospitals. We grouped themes at patient, provider, facility, system, and policy levels. Providers emphasized their desire for improved ART monitoring strategies, and frustration in response to restrictive policies for determining which patients were eligible to receive VL monitoring. Although many providers pled for expansion of monitoring to include all persons on ART, regardless of time on ART, the most salient provider-perceived barrier to VL monitoring implementation was the pressure of work associated with monitoring activities. The work burden was exacerbated by inefficient data management systems, highlighting a critical interaction between provider-, facility-, and system-level factors. Lack of integration between laboratory and clinical systems complicated the process for alerting providers when results were available, and these communication gaps were intensified by poor facility connectivity. Centralized second-line ART distribution was also noted as a barrier: providers reported that the time and expenses required for patients to collect second-line ART frequently obstructed referral. However, provider empowerment emerged as an unexpected facilitator of VL monitoring. For many providers, this was the first time they used an objective marker of ART response to guide clinical management. Providers’ knowledge of a patient's virological status increased confidence in adherence counseling and clinical decision-making. Results from our study provide unique insight into provider perceptions of VL monitoring and indicate the importance of policies responsive to individual and environmental challenges of VL monitoring program implementation. Findings may inform scale-up by helping policy-makers identify strategies to improve feasibility and sustainability of VL monitoring.

Keywords:

• HIV
• viral load monitoring
• provider perceptions
• resource-limited settings

Acknowledgements

We would like to thank the numerous ART patients and providers who made this research possible. In addition, we would like to thank Sayaka Hino (SH) for her contributions to transcript analysis, and Vivian Go for her thoughtful feedback on manuscript drafts.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was funded by Centers for Disease Control and Prevention Public Health Evaluation [grant number MW.10.1433]; the UNC Center for AIDS Research (P30 AI50410); and SER was funded by F30 MH098731–01 and T32 GM008719.