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Journal of Dermatological Treatment Volume 18, 2007 - Issue 2
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Case Report

Severe ichthyosis‐related disorders in children: Response to acitretin

Dr. Xibao Zhang Dermatological Department, Guangzhou Institute of Dermatology, Guangzhou, PR of ChinaCorrespondence[email protected]
,
Yuqing He Dermatological Department, Guangzhou Institute of Dermatology, Guangzhou, PR of China
,
Hua Zhou Department of Dermatology, Shenzhen Dermatological Hospital, Shenzhen, PR of China
,
Quan Luo Dermatological Department, Guangzhou Institute of Dermatology, Guangzhou, PR of China
&
Changxing Li Dermatological Department, Guangzhou Institute of Dermatology, Guangzhou, PR of China
Pages 118-122 | Received 24 Aug 2006, Accepted 25 Sep 2006, Published online: 12 Jul 2009
 
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Abstract

One case of keratitis ichthyosis deafness (KID) syndrome and two cases of bullous ichthyosiform erythroderma (BIE) were treated with systemic acitretin. The severe hyperkeratotic lesions improved dramatically with acitretin therapy in the KID case. Substantial improvement of the palmoplantar keratoderma was also observed. During follow‐up, laboratory results remained within normal limits and no skeletal abnormalities were detected. The two cases with BIE also showed good responses to acitretin. Long‐term follow‐up of these cases showed that signs and symptoms were well under control and no adverse effects were noted.

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