A pilot study for triple combination therapy with a low-fluence 1064 nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl’s Melanosis

Abstract

Background: Riehl’s melanosis presents as a diffuse gray-brown to black hyperpigmentation around face. The treatment of this disease is challenging and quite limited despite patients’ excessive psychological stresses.

Objective: In this prospective pilot study, we evaluated the efficacy and safety for a novel combination therapy based on low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl’s melanosis.

Methods: Totally eight patients with Riehl’s melanosis who had failed improvements previously received multiple sessions (10–18 times) of combination treatment regimen. The primary endpoint was clinical score by the physician and the secondary endpoints were clinical score by the patients, instrumental analysis using melanin and erythema values, and histopathological score.

Results: Among eight patients, three received “Almost clear” grade, the other five patients received “Marked improvement” grade at final visits. No serious adverse events and post-treatment downtime was observed. Mean Melanin and Erythema Indexes also showed significant decreases compared with baseline. Histopathologic examination confirmed a significantly greater reduction of melanin content in melanophages.

Conclusion: This combination method can be a viable option for Asian patients having Riehl’s melanosis with high risk of post-inflammatory hyperpigmentation, maintaining low-dose laser irradiation.

Keywords:

• Riehl’s melanosis
• combination therapy
• laser treatment

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.