Development of a combination therapy with silanols complexed with boron citrate and ablative-fractional laser for treatment of wrinkles and stretch marks

Abstract

Objective

The twenty first century’s progress in medicine and cosmetology triggered the search for effective and safe new cosmetics and procedures to fight with such problems as wrinkles or stretch marks. The study aimed to use the synergy of silanols with boron compounds and to develop treatment methods supported by a fractional-ablative laser.

Methods

Sixty-seven Caucasian people were enrolled in this study: 33 patients with facial and neck wrinkles and 34 patients with stretch marks. Preparations containing methylsilanetriol were pressed into the skin by means of oxygen infusion which were followed by the fractional-ablative laser treatments.

Results

The effectiveness of removal of wrinkles was better if combination therapy was used in the form of transdermal delivery of methylsilanetriol combined with laser therapy. The effectiveness of stretch marks removal by combination therapy was comparable to a two laser treatments and more effective than one laser therapy. Moreover, the use of products based on methylsilanetriol stabilized with boric citrate resulted in shortening the period of regeneration after the treatment with fractional-ablative laser by 29–58%.

Conclusion

The gel based on methylsilanetriol developed in this study can be successfully used after all laser treatments, but also those related to skin pricking to accelerate regeneration.

Keywords:

• Wrinkles
• stretch marks
• ablative-fractional laser
• silanols

Disclosure statement

Klaudyna Wolak is employee of company Inwex Sp. z o., which financially supported this study. Klaudyna Wolak declares that commercial affiliations did not play a role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript and only provided financial support in the form of authors’ salaries and/or research materials. Roksana Gruszkiewicz-Majczak has no conflicts of interest to declare.

Additional information

Funding

This study was supported by the research project from The National Center for Research and Development co-financed by INWEX Sp. z o. o. [POIG.01.04.00-26-287/13].