Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy

Abstract

Background

Chronic plantar ulcers in leprosy (CPUL) occur in areas that have a sensory and an autonomic nerve impairment where the wound healing takes longer. Framycetin gauze dressing (FGD) is best used in the wound healing process during the inflammatory phase because it contains antibiotics. Epigallocatechin gallate (EGCG) is the highest component in the extract of green tea that can accelerate blood vessel formation, has an anti-inflammatory effect, and reepithelialization.

Objective

To investigate the effect of topical EGCG 1% on the healing of CPUL.

Materials and methods

An analytical experimental approach comparing the topical EGCG 1% and FGD applied every 3 days up to 8 weeks on the healing of CPUL. Size of the ulcers, side effects and possible complications from both approaches were monitored weekly.

Results

Ulcer healing in the EGCG group was significantly better than the FGD group with significant clinical and statistical differences (p < .032). There were no side effects in both the study groups. Complications, such as an increase in the size of the ulcer, were noted in one subject in the control group. This may have been caused by FGD and claw foot condition.

Conclusions

EGCG 1% is more effective than FGD in accelerating the healing process of CPUL.

Keywords:

• Epigallocatechin gallate (EGCG)
• chronic plantar ulcers in leprosy (CPUL)
• framycetin gauze dressing (FGD)

Acknowledgments

This study was supported by the RSUD Dr. Soetomo Teaching Hospital/Medical Faculty of Airlangga University.

Disclosure statement

No potential conflict of interest was reported by the author(s).