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Articles

Efficacy of guselkumab versus secukinumab in subpopulations of patients with moderate-to-severe plaque psoriasis: results from the ECLIPSE study

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Pages 2317-2324 | Received 15 Jun 2021, Accepted 19 Jul 2021, Published online: 04 Aug 2021

Abstract

Purpose

Guselkumab, an interleukin (IL)-23 inhibitor, effectively treats moderate-to-severe plaque psoriasis.

Materials and methods

ECLIPSE, was a Phase 3, multicenter, 56-week, double-blinded, active-comparator study of guselkumab vs. secukinumab (IL-17A inhibitor) in patients with moderate-to-severe psoriasis. Patients were treated with guselkumab 100 mg (n = 534) or secukinumab 300 mg (n = 514) through week 44. Efficacy (at least a 90% and 100% improvement from baseline in Psoriasis Area and Severity Index [PASI 90 and PASI 100], Investigator’s Global Assessment [IGA] 0/1, and IGA 0) was analyzed across subpopulations defined by baseline: age (<45, 45 to <65, and ≥65 years old), body weight, body mass index (BMI), psoriasis disease severity (body surface area, disease duration, PASI, and IGA), psoriasis by body regions (head, trunk, upper and lower extremities), and prior psoriasis medication history at week 48.

Results

Overall, 1048 patients were randomized. At week 48, numerically greater proportions of patients achieved PASI 90, PASI 100, IGA 0/1, and IGA 0 with guselkumab vs. secukinumab regardless of baseline age, body weight, BMI, disease severity, body region, and prior medication. The largest differences were in patients ≥65 years old and patients weighing >100 kg.

Conclusions

Guselkumab treatment provided greater efficacy vs. secukinumab at week 48 in most subpopulations of patients with psoriasis.

Introduction

Newer classes of biologic agents, including interleukin (IL)-23 (Citation1–5) and IL-17A inhibitors (Citation6,Citation7), have enabled a greater proportion of patients with moderate-to-severe plaque psoriasis to achieve clear or almost clear skin. Despite these advances, not all biologics work as well in different patient populations, as differences in demographics and disease characteristics, especially weight, can affect the efficacy of biologics (Citation8–12), and these differences may change over time. Therefore, when selecting a therapy for an individual patient with psoriasis, it is often useful to understand the relative performance of each treatment within various clinically relevant and identifiable subpopulations.

Guselkumab, an IL-23p19 subunit inhibitor, has been shown to be highly efficacious and well-tolerated with up to 4 years of continuous treatment for moderate-to-severe psoriasis (Citation13,Citation14). In the recent Phase 3 comparator trial, ECLIPSE (Citation3), guselkumab showed superior long-term efficacy compared with secukinumab (an IL-17A inhibitor) at  week 48, the primary endpoint. In the current report, we evaluated the consistency of clinical response across various subpopulations of patients with psoriasis from the ECLIPSE study, including age, body weight, body mass index (BMI), psoriasis disease severity, psoriasis by body regions, and prior psoriasis medication history.

Patients and methods

Patients

Details of the Phase 3 ECLIPSE study (NCT03090100) and eligibility criteria have been previously presented (Citation3). Briefly, ECLIPSE was a multicenter, randomized, double-blinded, comparator-controlled study of guselkumab vs. secukinumab in patients with moderate-to-severe plaque psoriasis. Overall, eligible patients (≥18 years old) had moderate-to-severe plaque-type psoriasis defined as Psoriasis Area and Severity Index (PASI) ≥12, Investigator’s Global Assessment [IGA] score ≥3 (moderate), body surface area (BSA) involvement ≥10%, a history of psoriasis for ≥6 months, and were candidates for phototherapy or systemic therapy (Citation3). The study protocol was approved by Institutional Review Boards at each site and participants provided written informed consent prior to any study-related procedures. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Study design

The study design has been previously presented (Citation3). Patients were randomized in a 1:1 ratio at baseline to receive guselkumab 100 mg (n = 534) subcutaneously at weeks 0, 4, 12, and every-8-weeks thereafter through week 44, or secukinumab 300 mg (n = 514) administered subcutaneously as two 150-mg injections at weeks 0, 1, 2, 3, 4, and every-4-weeks thereafter through week 44. Patients randomized to guselkumab also received placebo injections to match the number and frequency of secukinumab injections to maintain the blind (Citation3).

Efficacy assessments

Efficacy was assessed at week 48 using data from ECLIPSE in the following baseline subpopulations: (1) age; (2) body weight and BMI; (3) psoriasis disease severity; (4) psoriasis by body regions (head, trunk, upper extremities, and lower extremities); and (5) prior psoriasis medication history. Endpoints included at least a 90% improvement from baseline in PASI (PASI 90), PASI 100, IGA 0/1 (cleared or minimal), and IGA 0 (cleared) at week 48 compared with secukinumab.

PASI measures psoriasis severity with investigator-determined regional subscores for erythema, induration, scaling, and percentage of BSA affected (Citation15). The regional PASI components of head, trunk, and upper, and lower extremities were assessed. IGA captures the investigator’s assessment of the patient’s psoriasis lesions (induration, erythema, and scaling) with a score of clear (0), minimal (1), mild (2), moderate (3), or severe (4).

Statistical analyses

Analyses were performed using descriptive statistics data for the identified subpopulations in the ECLIPSE study for the endpoints described above. Differences in the proportion of patients achieving a clinical response and the associated 95% confidence intervals (CIs) for the between group differences were calculated for the analyses of PASI 90, PASI 100, IGA 0/1, and IGA 0 by subpopulation. The 95% CIs were calculated by Wald asymptotic confidence limits with continuity correction. Data handling rules were the same as those used for the primary and major secondary analyses (Citation3). The analyses of PASI 90 and PASI 100 at week 48 by baseline body weight were post-hoc analyses. Testing hypotheses were not performed for subgroup analyses due to multiplicity adjustment considerations and lack of sufficient power to detect subgroup effects for some categories of baseline factors.

Results

Baseline demographics and disease characteristics

Baseline demographics and disease characteristics were generally comparable between patients treated with guselkumab and secukinumab (). Overall, most patients were White (93.4%), men (67.5%), approximately 46 years old, with a mean BMI of 29.9. Patients had approximately 24% BSA involvement, 99.9% had moderate to severe IGA scores, and mean PASI was 20.0. At baseline, prior psoriasis medication history was comparable between the treatment groups ().

Table 1. Baseline demographics and disease characteristics from ECLIPSE study (Citation3).

Efficacy by age at baseline

PASI 90 and PASI 100 response rates were numerically higher at week 48 in the guselkumab group than the secukinumab group across all 3 age categories: <45 years, 45 to <65 years, and ≥65 years (). Similarly, IGA 0/1 responses (<45 years: 85.8% [guselkumab] vs. 81.3% [secukinumab], between group difference 95% CI: [-2.4, 11.5]; 45 to <65 years: 85.4 vs. 73.4%, 95% CI: [4.1, 19.9]; ≥65 years: 79.6 vs. 44.4%, 95% CI: [15.1, 55.3]) and IGA 0 responses (<45 years: 64.6 vs. 58.0%, 95% CI: [-2.5, 15.6]; 45 to <65 years: 61.4 vs. 46.4%, 95% CI: [5.5, 24.5]; ≥65 years: 55.6 vs. 24.4%, 95% CI: [10.8, 51.4]) were also numerically higher at week 48 for guselkumab-treated patients compared with secukinumab-treated patients, respectively.

Figure 1. Proportion of patients achieving at least a 90% improvement in Psoriasis Area and Severity Index (PASI 90) or PASI 100 response at week 48 by baseline age. 95% CI: 95% confidence interval; yrs: years.

Figure 1. Proportion of patients achieving at least a 90% improvement in Psoriasis Area and Severity Index (PASI 90) or PASI 100 response at week 48 by baseline age. 95% CI: 95% confidence interval; yrs: years.

Efficacy by baseline body weight and BMI

The proportions of patients achieving PASI 90 or PASI 100 responses at week 48 by baseline body weight (from <60 to >110 kilograms [kg]) were numerically higher for guselkumab-treated vs. secukinumab-treated patients, especially in the heaviest patients (>100 kg) (). Similarly, the proportion of patients achieving IGA 0/1 responses at week 48 were generally numerically higher for guselkumab-treated vs. secukinumab-treated patients, respectively (≤60 kg: 77.5% [guselkumab] vs. 76.9% [secukinumab]; >60 to 70 kg: 85.1 vs. 74.5%; >70 to 80 kg: 90.2 vs. 79.3%; >80 to 90 kg: 91.8 vs. 79.8%; >90 to 100 kg: 79.4 vs. 81.3%; >100 to 110 kg: 78.7 vs. 69.8%; >110 kg: 86.1 vs. 55.7%) and for IGA 0, respectively (≤60 kg: 52.5 vs. 50.0%; >60 to 70 kg: 65.7 vs. 60.0%; >70 to 80 kg: 68.5 vs. 59.8%; >80 to 90 kg: 71.4 vs. 48.7%; >90 to 100 kg: 57.7 vs. 53.1%; >100 to 110 kg: 62.3 vs. 44.4%; >110 kg: 50.6 vs. 34.4%).

Figure 2. Proportion of patients achieving (a) at least a 90% improvement in Psoriasis Area and Severity Index (PASI 90) or (b) PASI 100 response at week 48 by baseline body weight deciles. kg: kilograms.

Figure 2. Proportion of patients achieving (a) at least a 90% improvement in Psoriasis Area and Severity Index (PASI 90) or (b) PASI 100 response at week 48 by baseline body weight deciles. kg: kilograms.

Likewise, the proportions of patients achieving PASI 90 at week 48 by baseline BMI were numerically higher for guselkumab-treated vs. secukinumab-treated patients (normal [<25 kg/m2]: 88.1 vs. 75.2%; overweight [≥25 to <30 kg/m2]: 84.1 vs. 73.4%; obese [≥30 kg/m2]: 82.5 vs. 65.3%). Similar results were reported for PASI 100 (normal: 64.2 vs. 57.8%; overweight: 61.4 vs. 53.7%; obese: 52.5 vs. 40.4%), IGA 0/1 (normal: 85.8 vs. 77.1%; overweight: 86.9 vs. 81.9%; obese: 83.0 vs. 69.3%), and IGA 0 (normal: 68.7 vs. 60.6%; overweight: 64.2 vs. 54.2%; obese: 57.0 vs. 43.1%).

Efficacy by baseline disease severity

At week 48, the proportions of patients achieving PASI 90 or PASI 100 responses were numerically higher for guselkumab-treated vs. secukinumab-treated patients for all subgroups defined by baseline disease severity including: baseline BSA, disease duration, baseline PASI, and baseline IGA score (). Likewise, the proportion of patients achieving IGA 0/1 responses by baseline disease characteristics were numerically higher for guselkumab-treated vs. secukinumab-treated patients, respectively (BSA involvement <20%: 85.9 vs. 80.8%, 95% CI: [-1.9, 12.1]; BSA involvement ≥20%: 84.2 vs. 69.7%, 95% CI: [7.3, 21.8]; psoriasis disease duration <15 years: 84.7 vs. 77.0%, 95% CI: [0.1, 15.3]; psoriasis disease duration ≥15 years: 85.3 vs. 73.1%, 95% CI: [5.3, 19.1]; PASI <20: 83.1 vs. 78.8.%, 95% CI: [-1.9, 10.5]; PASI ≥20: 88.4 vs. 68.1%, 95% CI: [11.7, 28.9]; IGA <4: 86.2 vs. 75.8%, 95% CI: [4.8, 16.1]; IGA = 4: 81.1 vs. 72.1%, 95% CI: [-2.3, 20.2]), and IGA 0 responses (BSA involvement <20%: 64.3 vs. 57.5%, 95% CI: [-2.3, 15.8]; BSA involvement ≥20%: 60.4 vs. 44.2%, 95% CI: [7.7, 24.7]; psoriasis disease duration <15 years: 63.5 vs. 57.3%, 95% CI: [-3.2, 15.5]; psoriasis disease duration ≥15 years: 61.2 vs. 44.4%, 95% CI: 8.5, 25.2]; PASI <20: 61.3 vs. 53.1%, 95% CI: [0.5, 16.0]; PASI ≥20: 63.7 vs. 45.7%, 95% CI: [7.5, 28.3]; IGA <4: 64.1 vs. 51.3%, 95% CI: [5.8, 19.9]; IGA = 4: 55.9 vs. 47.5%, 95% CI: [-4.8, 21.5]).

Figure 3. Proportion of patients achieving at least a 90% improvement in Psoriasis Area and Severity Index (PASI 90) or PASI 100 response at week 48 by baseline disease severity. 95% CI: 95% confidence interval; BSA: body surface area; IGA: Investigator’s Global Assessment; yrs: years.

Figure 3. Proportion of patients achieving at least a 90% improvement in Psoriasis Area and Severity Index (PASI 90) or PASI 100 response at week 48 by baseline disease severity. 95% CI: 95% confidence interval; BSA: body surface area; IGA: Investigator’s Global Assessment; yrs: years.

Efficacy by baseline psoriasis per body region

At week 48, numerically greater improvements in PASI component scores were reported for the following body regions: head, trunk, upper extremities, and lower extremities in guselkumab-treated patients compared with secukinumab-treated patients ().

Table 2. Efficacy of Psoriasis Area and Severity Index component responses by body region at week 48.

Efficacy by prior psoriasis medication history

Regardless of previous psoriasis medication history, a numerically greater proportion of guselkumab-treated patients achieved PASI 90 or PASI 100 responses at week 48 compared with secukinumab-treated patients (). Similar results were observed for IGA 0/1 responses (phototherapy: 86.1 vs. 77.0%, 95% CI: [2.2, 16.0]; non-biologic systemics or biologics: 84.8 vs. 75.5%, 95% CI: [2.9, 15.6]; non-biologic systemics: 85.1 vs. 76.3%, 95% CI: [2.0, 15.7]; biologic: 84.0 vs. 71.8%, 95% CI: [2.3, 22.1]; tumor necrosis factor-alpha (TNFα) inhibitor: 81.7 vs. 64.7%, 95% CI: [2.6, 31.4]; IL-12/23 inhibitors: 77.8 vs. 63.6%, 95% CI: [-6.8, 35.1]; IL-17 inhibitors: 87.0 vs. 75.4%, 95% CI: [-2.8, 25.9]) and for IGA 0 (phototherapy: 61.6 vs. 49.8%, 95% CI: [3.1, 20.4]; non-biologic systemics or biologics: 61.3 vs. 47.7%, 95% CI: [-1.9, 18.7]; non-biologic systemics: 61.2 vs. 46.7%, 95% CI: [6.0, 23.0]; biologic: 60.9 vs. 47.7%, 95% CI: [1.5, 25.0]; TNFα inhibitor: 58.5 vs. 43.5%, 95% CI: [-1.2, 31.2]; IL-12/23 inhibitors: 57.8 vs. 40.9%, 95% CI: [-5.9, 39.6]; IL-17 inhibitors: 60.9 vs. 52.2%, 95% CI: [-9.2, 26.6]) at week 48, with guselkumab-treated patients having numerically greater responses compared with secukinumab-treated patients, respectively.

Figure 4. Proportion of patients achieving at least a 90% improvement in Psoriasis Area and Severity Index (PASI 90) or PASI 100 response at week 48 by prior psoriasis medication history at baseline. 95% CI: 95% confidence interval; IL: interleukin; PUVA: psoralen plus ultraviolet A; TNFα: tumor necrosis factor alpha; UVB: ultraviolet B.

Figure 4. Proportion of patients achieving at least a 90% improvement in Psoriasis Area and Severity Index (PASI 90) or PASI 100 response at week 48 by prior psoriasis medication history at baseline. 95% CI: 95% confidence interval; IL: interleukin; PUVA: psoralen plus ultraviolet A; TNFα: tumor necrosis factor alpha; UVB: ultraviolet B.

Discussion

With the approval of newer biologic agents, including the IL-23 and IL-17 inhibitors, increased efficacy with complete skin clearance is often attainable (Citation1,Citation2,Citation4–6,Citation16–18). The ECLIPSE study (Citation3) provided direct efficacy comparisons between therapies from the two newest and most effective psoriasis drug classes available. Distinct domains of psoriasis, such as scalp, nail, and hand/feet (Citation17,Citation19–21), and different subgroups, defined by weight (Citation9,Citation22,Citation23) and previous therapy, may respond differently to targeted treatments. Here, we showed that guselkumab treatment resulted in numerically higher levels of efficacy compared with secukinumab treatment in most subpopulations of patients described above, including in patients with more severe baseline disease (baseline BSA >20%, PASI >20) and in patients previously-treated with systemics or biologics.

Notably, guselkumab was more effective in heavier patients, which is important because most patients with psoriasis are overweight (Citation24,Citation25), and obesity may affect a patient’s response to treatment (Citation26). Perhaps the most striking difference occurred in patients 65 years of age and older; patients in this age subgroup who received guselkumab had much better clinical responses than patients in this age group who received secukinumab. Patients with longer disease duration at baseline treated with guselkumab also responded significantly better than those treated with secukinumab. In real-world practice, despite the variety of treatment options for psoriasis, some patients continue to experience psoriasis activity (Citation27). When considering available treatment options, it is useful for clinicians to have comparative data, like those presented here, when making treatment decisions for patients of varying demographics and disease characteristics.

A limitation of this analysis was that efficacy data were reported only through 48 weeks; longer term efficacy comparisons would be useful, but the ECLIPSE study was limited to 1 year. In addition, this report was a subgroup analysis. Also, when considering prior medication history, there could be recall bias. We also did not present comparisons between these drugs in terms of their efficacy on psoriatic joint disease. Of note, both guselkumab and secukinumab are now approved to treat active psoriatic arthritis (Citation28,Citation29). Safety comparisons within each subpopulation were also not assessed between the two treatments, as the safety of each of treatment was relatively similar in the full set of patients through week 48 (Citation3).

In conclusion, guselkumab treatment provided greater efficacy compared with secukinumab at week 48 across different psoriasis patient subpopulations defined by baseline characteristics, including age, body weight, BMI, disease severity, affected body region, and prior psoriasis medication history. These findings should optimize patient care by guiding clinicians in treatment selection for diverse patient populations.

Ethical approval

The study protocol for the ECLIPSE study (NCT03090100) was approved by Institutional Review Boards at each site. All participants provided written informed consent.

Acknowledgments

The authors wish to thank Kristin Ruley Sharples, PhD, of Janssen Scientific Affairs, LLC, Horsham, PA for her writing and editorial support in the preparation of this manuscript.

Disclosure statement

A. Blauvelt has served as a scientific adviser and/or clinical study investigator for AbbVie, Almirall, Arena, Athenex, Boehringer Ingelheim, Bristol Myers Squibb, Dermavant, Eli Lilly, Evommune, Forte, Galderma, Incyte, Janssen, LEO Pharma, Novartis, Pfizer, Rapt, Regeneron, Sanofi Genzyme, Sun Pharmaceutical, and UCB Pharma. A. W. Armstrong has served as a research investigator and/or scientific advisor to LEO Pharma, AbbVie, UCB, Janssen, Eli Lilly, Novartis, Ortho Dermatologics, Sun Pharmaceutical, Dermavant, Bristol Myers Squibb, Sanofi, Regeneron, Dermira, and Modmed. R. G. Langley has served/received compensation in the form and or Honoria as Principle I investigator for/or on the scientific advisory board/or served as a speaker for AbbVie, Amgen, Boehringer Ingelheim, Celgene, Janssen, LEO Pharma, Eli Lilly, Merck, Novartis, Pizer, Sun Pharmaceutical, and UCB Pharma. K. Gebauer has served as an advisory board member and investigator for AbbVie, Janssen, LEO Pharma, Sun Pharmaceutical, and UCB, and has received educational grants from AbbVie, Janssen, Sanofi, and Sun Pharmaceutical. L. C. Guenther has served as a consultant, investigator, and speaker for AbbVie, Amgen, Bausch Health, Celgene, Eli Lilly, GlaxoSmithKline, Janssen, LEO Pharma, Merck, Novartis, Pfizer, and Sun Pharmaceutical; has been a speaker and consultant for Actelion; and has been an investigator for Boehringer Ingelheim, and UCB. C. Paul has served as an investigator or consultant for AbbVie, Almirall, Astellas, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Eli Lilly, Galderma, Janssen Cilag, LEO Pharma, Merck, Novartis, Pfizer, Regeneron, Sanofi, and UCB Pierre Fabre; K. Reich has served as advisor and/or paid speaker for and/or participated in clinical trials sponsored by AbbVie, Affibody, Almirall, Amgen, Avillion, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Covagen, Dermira, Eli Lilly, Forward Pharma, Fresenius Medical Care, Galapagos, GlaxoSmithKline, Janssen, Janssen-Cilag, Kyowa Kirin, LEO Pharma, Medac, Merck Sharp & Dohme, Novartis, Miltenyi Biotec, Ocean Pharma, Pfizer, Regeneron, Samsung Bioepis, Sanofi, Sun Pharmaceutical, Takeda, UCB, Valeant, and Xenoport; B. Randazzo, S. Flavin, M.-C. Hsu, and Y. You are all employees of Janssen Research & Development, LLC, and own stock in Johnson & Johnson, of which Janssen is a subsidiary.

Data availability statement

The data sharing policy of Janssen Pharmaceutical Companies of Johnson & Johnson is available at https://www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at http://yoda.yale.edu.

Additional information

Funding

This study was funded by Janssen Research & Development, LLC, Spring House, PA, USA. D. Thaçi reports personal fees from AbbVie, Almirall, Amgen, Asana Biosciences, Biogen Idec, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Janssen-Cilag, Kyowa Kirin, LEO Pharma, Eli Lilly, Novartis, Regeneron, Sandoz, Sanofi-Aventis, Pfizer, and UCB, grants from AbbVie, Celgene, LEO Pharma, and Novartis. J. Bagel has received research funds payable to Psoriasis Treatment Center from AbbVie, Amgen, Arcutis Biotherapeutics, Boehringer Ingelheim, Bristol Myers Squibb, Celgene Corporation, Corrona LLC, Dermavant Sciences, LTD, Dermira, UCB, Eli Lilly, Glenmark Pharmaceuticals Ltd., Janssen Biotech, Kadmon Corporation, LEO Pharma, Lycera Corp, Menlo Therapueutics, Novartis, Pfizer, Regeneron Pharmaceuticals, Sun Pharma, Taro Pharmaceutical Industries Ltd., and Ortho Dermatologics; consultant fees from AbbVie, Amgen, Celgene Corporation, Bristol Myers Squibb, Eli Lilly, Janssen Biotech, Novartis, Sun Pharmaceutical , and UCB; and speaking fees from AbbVie, Celgene Corporation, Eli Lilly, Janssen Biotech, and Novartis.

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