The effect of simultaneous exposure of human fibroblasts to fluoride and moderate intensity static magnetic fields

Abstract

Background: The combined effect of exposure to a static magnetic field (SMF) and potentially toxic agents is a crucial research area, mainly due to occupational and environmental exposure to these factors. The aim of this study was to evaluate the effect of the simultaneous exposure of human fibroblasts to fluoride and a SMF.

Materials and methods: Control fibroblasts and fibroblasts that had been treated with fluoride were subjected to an SMF at a moderate induction (0.45, 0.55 and 0.65 T). The intracellular reactive oxygen species production, the concentration of malondialdehyde and the activities of superoxide dismutase and glutathione peroxidase were measured.

Results: Our investigations revealed that a moderate SMF does not enhance the action of fluoride in inducing oxidative stress by generating free radicals

Conclusions: A moderate SMF may be a factor that weakens the toxic action of fluoride, which is important for the health of individuals that are co-exposed to an SMF and fluoride ions (F⁻) from occupational and environmental sources.

Keywords:

• Fluoride
• static magnetic field
• antioxidant status
• reactive oxygen species
• fibroblasts

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This study was supported by grant no. KNW-2-I26/N/7/K from the Medical University of Silesia, Katowice, Poland.

Notes on contributors

Magdalena Kimsa-Dudek

Magdalena Kimsa-Dudek – PhD, Head of the Department of Nutrigenomics and Bromatology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice.

Agnieszka Synowiec-Wojtarowicz

Agnieszka Synowiec-Wojtarowicz – PhD, research assistant in the Department of Nutrigenomics and Bromatology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice.

Małgorzata Derewniuk

Małgorzata Derewniuk – MSc, pharmacist.

Monika Paul-Samojedny

Monika Paul-Samojedny – DSc, assistant professor in the Department of Medical Genetics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice.

Katarzyna Pawłowska-Góral

Katarzyna Pawłowska-Góral – DSc, assistant professor in the Department of Nutrigenomics and Bromatology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice.