Abstract
Purpose
This article will briefly review the origins and evolution of functional genomics, first describing the experimental technology, and then some of the approaches applied to data analysis and visualization. It will emphasize application of functional genomics to radiation biology, using examples from the author’s work to illustrate several key types of analysis. It concludes with a look at non-coding RNA, alternative reading of the genome, and single-cell transcriptomics, some of the innovative areas that may help to shape future research in radiation biology and oncology.
Conclusions
Transcriptomic approaches have provided insight into many areas of radiation biology and medicine, and innovations in technology and data analysis approaches promise continued contributions to radiation science in the future.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
Notes on contributors
Sally A. Amundson
Sally A. Amundson is an Associate Professor in the Center for Radiological Research at Columbia University Irving Medical Center in New York. She is a member of the National Council on Radiation Protection and Measurements, the Nuclear and Radiation Studies Board of the National Academy of Science, and at the time of writing is serving as Vice President of the Radiation Research Society.