Abstract
Purpose
The aim of this review is to discuss previous studies on the function of stem cells in radiation-induced damage, and the factors affecting these processes, in the hope of improving our understanding of the different stem cells and the communication networks surrounding them. This is essential for the development of effective stem cell-based therapies to regenerate or replace normal tissues damaged by radiation.
Conclusion
In salivary glands, senescence-associated cytokines and inflammation-associated cells have a greater effect on stem cells. In the intestinal glands, Paneth cells strongly affect stem cell-mediated tissue regeneration after radiation treatment. In the pancreas, β-cells as well as protein C receptor positive (Procr) cells are expected to be key cells in the treatment of diabetes. In the bone marrow, a variety of cytokines such as CXC-chemokine ligand 12 (CXCL12) and stem cell factor (SCF), contribute to the functional recovery of hematopoietic stem cells after irradiation.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
Notes on contributors
Zheran Liu
Zheran Liu is a PhD student at West China Hospital of Sichuan University with an interest in radiation injury.
Liqiang Hu
Liqiang Hu works at West China Hospital of Sichuan University and is interested in radiation injuries.
Ling He
Ling He is a PhD student from West China Hospital of Sichuan University with an interest in radiation injury.
Lianlian Yang
Lianlian Yang is a master's student at West China Hospital of Sichuan University with an interest in radiation injury.
Zijian Qin
Zijian Qin is a master's student at West China Hospital of Sichuan University with an interest in radiation injury.
Yuping Xie
Yuping Xie works at Chengdu First People's Hospital and is interested in radiation-related injuries.
Xingchen Peng
Xingchen Peng works at West China Hospital of Sichuan University and is interested in radiation irradiation injuries.
Lei Dai
Lei Dai works at Sichuan University and is interested in radiation-related injuries.