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Original Article

The Influence of Radiation Quality and Oxygen on Strand Breakage in Dry DNA

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Pages 25-40 | Received 07 May 1970, Accepted 15 May 1970, Published online: 03 Jul 2009
 

Summary

DNA isolated from T7 phage or deposits of this phage were irradiated with various qualities of radiation, including track-segment irradiations by charged heavy particles. The amount of single- and double-strand breakage was determined by analysis of the sedimentation boundary in an analytical ultracentrifuge. The results show that

(1) a single-strand break is produced on average for each energy-loss event in the DNA molecule

(2) an energy-loss event has a chance of about 1 in 20 of producing a double-strand break, with little dependence on LET in the range up to 100 keV/μm

(3) there is no significant effect of oxygen on the production of either single-or double-strand breaks.

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