The Formation of Photoreactivable Damage by Direct Excitation of DNA in X-irradiated E. Coli Cells

V.V. Duba Department of Medical Physics, Institute of Medical Radiology, Academy of Medical Sciences of U.S.S.R., Obninsk, 249020, Kaluga Region, U.S.S.R.

V.A. Pitkevich Department of Radioactive Preparations, Institute of Medical Radiology, Academy of Medical Sciences of U.S.S.R., Obninsk, 249020, Kaluga Region, U.S.S.R.

N.G. Selyova Department of Medical Physics, Institute of Medical Radiology, Academy of Medical Sciences of U.S.S.R., Obninsk, 249020, Kaluga Region, U.S.S.R.

I.V. Petrova Department of Radioactive Preparations, Institute of Medical Radiology, Academy of Medical Sciences of U.S.S.R., Obninsk, 249020, Kaluga Region, U.S.S.R.

M.N. Myasnik Department of Medical Physics, Institute of Medical Radiology, Academy of Medical Sciences of U.S.S.R., Obninsk, 249020, Kaluga Region, U.S.S.R.

Summary

The role of the direct excitation process in the formation of photoreactivable damage (pyrimidine dimers) in E. coli WP2 hcr⁻exr⁻ cells has been studied. The pyrimidine dimers were detected by photoreactivation following anoxic irradiation by X-rays (220 kVp). The dose modifying factor (DMF) is 1·28 ± 0·09. A biophysical model is used for a theoretical examination of the importance of the direct excitation process in the formation of photoreactivable damage and the experimental data are consistent with this model.

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The Formation of Photoreactivable Damage by Direct Excitation of DNA in X-irradiated E. Coli Cells

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The Formation of Photoreactivable Damage by Direct Excitation of DNA in X-irradiated E. Coli Cells

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