The r.b.e. of Fast Fission Neutrons (2 MeV) for Chronic Radiation Damage of the Large Bowel of Rats after Single Dose and Fractionated Irradiation

Summary

Late damage in the rectum of rats was studied after local irradiation with 2 MeV fast fission neutrons and the results were compared with those for 300 kV X-rays. A similarity between latency times, and between clinical, gross pathological and histological appearances of the rectal obstruction after the two types of radiation was observed. The r.b.e. evaluated from ED 50 200 days values was 1·8 for single doses, 2·1 for two fractions and 3 for five fractions and these are similar to r.b.e.s from other investigations of chronic intestinal radiation damage. Using linear quadratic analysis, a limiting r.b.e. of 5 was obtained. The β-values are similar for both radiation qualities. Because of the high γ-contamination (25 per cent) in the RENT I beam a possible correction of the r.b.e. for neutrons only, assuming interaction, is discussed.

• bowel stenosis
• chronic radiation damage
• neutrons
• fractionation