Rejoining of Double Strand Breaks in Normal Human and Ataxia-telangiectasia Fibroblasts after Exposure to ⁶⁰Co γ-rays, ²⁴¹Am α-particles or Bleomycin

Summary

The rejoining of DNA double strand breaks (dsb) induced by ⁶⁰Co γ-rays, ²⁴¹Am α-particles or bleomycin was measured by neutral filter elution. In agreement with their colony-forming ability, ataxia-telangiectasia cells (AT2BE) and normal fibroblasts exhibited similar dsb rejoining capacity following α-irradiation, but showed marked differences in the rejoining kinetics of dsb induced by γ-rays or bleomycin.

• dsb rejoining
• ataxia telangiectasia
• ionizing radiation
• bleomycin