Induction of Double-strand Breaks Following Neutron Capture by DNA-bound ¹⁵⁷Gd

Roger F. Martin Molecular Science Group, Peter MacCallum Cancer Institute, 481 Lt. Lonsdale Street, Melbourne, Victoria, Australia

Glenn D'Cunha Australian Nuclear Science and Technology Organization, Lucas Heights Research Laboratories, New Illawarra Road, Menai, NSW 2234, Australia

Marshall Pardee Molecular Science Group, Peter MacCallum Cancer Institute, 481 Lt. Lonsdale Street, Melbourne, Victoria, Australia

Barry J. Allen Australian Nuclear Science and Technology Organization, Lucas Heights Research Laboratories, New Illawarra Road, Menai, NSW 2234, Australia

Summary

Irradiation of plasmid DNA/Gd³⁺ mixtures with thermal neutrons induces DNA double-strand breaks (dsb). However, the extent of breakage is markedly reduced by sequestering the Gd³⁺ from DNA by addition of EDTA. Since the ¹⁵⁷Gd neutron capture event involves some internal conversion, we suggest that the DNA dsb induction results from Auger electron emission.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Induction of Double-strand Breaks Following Neutron Capture by DNA-bound ¹⁵⁷Gd

Information for

Open access

Opportunities

Help and information

Induction of Double-strand Breaks Following Neutron Capture by DNA-bound 157Gd

Summary

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature

Induction of Double-strand Breaks Following Neutron Capture by DNA-bound ¹⁵⁷Gd