Testing of Methyleneiminodiacetic-catechol and Other Aromatic Chelating Agents for Decorporation of ²³⁸Pu and ²⁴¹Am in Rats

Summary

The removal of ²³⁸Pu and ²⁴¹Am by five chelating agents prepared in China was compared in pilot experiments with removal by Ca-DTPA and LICAM(C). The most promising substance is quinamic acid (a methyliminodiacetic poly-quinoline derivative, code name 811 or 703-73), especially in combination with Ca-DTPA. However, the best over-all reduction of both ²³⁸Pu and ²⁴¹Am in all the organs studied was achieved by Ca-DTPA administered at a ten-fold human equivalent dosage.