Insights into the acute effect of anti-inflammatory drugs on activated sludge systems with high solids retention time

ABSTRACT

The increase in the occurrence of the pharmaceuticals in the environmental compartments is becoming emerging concern as it reflects their inefficient treatment in the wastewater treatment plants which are the main sources of these micropollutants. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed and frequently detected pain medications in wastewater treatment plants. A lab scale sequencing batch reactor (SBR) was operated for seven months and acute inhibitory effect of NSAIDs on activated sludge was tested with respirometry. Culture amendment with different concentrations of NSAIDs in the presence as well as absence of nitrification inhibitor resulted in considerable variation in the oxygen uptake rate (OUR) profiles. The decrease in OUR and nitrate production rate governed with reduced heterotrophic and nitrification activity. The kinetics of half saturation for growth and maximum autotrophic growth rates are determined to be affected negatively by the acute impact of anti-inflammatory pharmaceuticals even at the environmentally relevant concentrations. High removal of tested NSAIDs was observed even for the first time introduce with these compounds.

GRAPHICAL ABSTRACT

KEYWORDS:

• Micropollutants
• emerging pollutants
• nitrification
• NSAIDs
• respirometry

Acknowledgements

This work was supported by the [Scientific and Technological Research Council of Turkey, TUBITAK] under grant [117Y087]; [TUBA-GEBIP Award of Turkish Academy of Sciences]; and [BAGEP Award of Science Academy, Turkey].

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the [Scientific and Technological Research Council of Turkey, TUBITAK] under grant [grant number 117Y087]; [TUBA-GEBIP Award of Turkish Academy of Sciences]; and [BAGEP Award of Science Academy, Turkey].