Lead distribution in blood and organs of mice exposed to lead by vein injection

Abstract

To study lead (Pb) distribution in organs and blood in the case of Pb poisoning, mice were firstly exposed to Pb as 0.1 mL or 0.2 mL of lead nitrate solution (0.1 mg/mL) by vein injection every other day. Then, after metabolic absorption, the Pb level in the blood and organs of the mice was measured using flame atomic absorption spectrometry. The resulting data showed that 93% of Pb in blood wass accumulated in red cells, but this percentage slightly decreased with increasing exposure time and injection volume. For other target organs, the highest Pb level was in the kidney, followed by the liver, spleen, heart and lung, and was lowest in the brain. Moreover, the Pb level in the heart and brain is in a growth trend at all times for 0.1 mL and 0.2 mL of Pb injection exposure in 15 days, while the growth trend of Pb in other target organs become slow for 0.2 mL of injection after exposure Pb 11 days.

Keywords:

• lead
• vein injection
• mice
• distribution
• flame atomic absorption spectrometry

Acknowledgement

This work was supported by China Research Foundation Grant funded by the Government of China (20235010).