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Original Articles

Are changes in everyday memory over time in autopsy-confirmed Alzheimer's disease related to changes in reported behaviour?

Pages 201-217 | Published online: 22 Sep 2010
 

Abstract

Performance on an augmented version of the Rivermead Behavioural Memory Test (RBMT) was examined in 48 people with autopsy-confirmed Alzheimer's disease and compared with Mini Mental State Examination (MMSE) score and with ratings on a behavioural questionnaire. Highly significant correlations were found between RBMT and MMSE scores but there was little evidence of any systematic relationship between memory deficits and reported behavioural change. Longitudinal analyses of change over time were carried out on the scores of 22 participants who remained in the study for at least three years. Scores above zero were recorded for all but three RBMT items. Significant effects of reported change in two aspects of behaviour (losing one's way around the house; knowing the time of day) were identified on a number of memory test items. These results are interpreted as suggesting general rather than specific relationships between decline in cognition and behavioural change in Alzheimer's disease.

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