Individual exposure to nitrogen dioxide and adverse pregnancy outcomes in Kaunas study

Abstract

Several epidemiological studies have found some evidence suggesting that exposure to air pollutants during pregnancy increases the risk of adverse birth outcomes. In this cohort study, we assessed individual maternal exposure to nitrogen dioxide (NO₂) during pregnancy and examined the association between the exposure and pregnancy outcomes, such as low birth weight (LBW), term low birth weight (TLBW), small for gestational age (SGA) and preterm birth (PB). 3292 women living in Kaunas city, Lithuania, data and their singleton newborns were included in the study. Exposure to NO₂ was assigned to each individual subject during pregnancy based on residential address using an AIRVIRO dispersion model and geographic information system (GIS). The results of the logistic regression analysis showed that LBW risk increased statistically significantly with increasing exposure to NO₂. Increased maternal exposure to NO₂ tended to increase the risk for TLBW, SGA and PB.

Keywords:

• Nitrogen dioxide
• exposure
• modelling
• pregnancy outcomes