Altered phagocytic capacity due to acute exposure and long-term post-exposure to pesticides used for vector-borne disease as dengue

ABSTRACT

Spinosad and temefos are widely used pesticides for chemical control of dengue vector-borne disease (Aedes aegypti). The aim of this study was to compare the effect of acute exposure (7 days) to spinosad (0.5 mg A.I. L⁻¹) and temefos (10 mg A.I. L⁻¹), concentrations used by the Mexican Ministry of Health, on phagocytic capacity (PC) of mononuclear cells of guppies fish (Poecilia reticulata), as well as to assess PC in fish, at 96 days after exposure to those pesticides. Obtained results indicated that spinosad did not alter PC, while an acute exposure to temefos significantly affected phagocytosis and this parameter was maintained downed even 96 days after the acute exposure, suggesting that the immunotoxic effects of temefos may be chronic.

KEYWORDS:

• Phagocytosis
• mononuclear cells
• pesticides
• temephos
• spinosad

Disclosure statement

There is no conflict of interest and the authors declare that they have no direct relationship with the previously mentioned commercial entitles or any other related.

Additional information

Funding

This work was performed in the Laboratorio Nacional para la Investigación en Inocuidad Alimentaria (LANIIA)-Unidad Nayarit, as part of the Project CONACyT-CB-2017-2018 A1-S-53561.