LDL receptor-related protein 5 rs648438 polymorphism is associated with the risk of skeletal fluorosis

ABSTRACT

To investigate the potential association between LRP5 rs648438 polymorphism and the risk of skeletal fluorosis (SF) was evaluated in a cross-sectional case–control study conducted in Shanxi, China, in 2019. A total of 973 individuals were enrolled in this study, in which cases and controls were 346 and 627, respectively. SF was diagnosed according to the standard WS/192–2008 (China). The LRP5 rs648438 was detected by the multiple PCR and sequencing. LRP5 rs648438 was found to follow a dominant genetic model using a web-based SNP-STATS software. Logistic regression analysis found that the TC/CC genotype of LRP5 rs648438 might be a protective factor for SF. When stratified by gender, this protective effect of TC/CC genotype in rs648438 was pronounced in males. There was an interaction between gender and rs648438 on risk of SF. Our study suggested that TC/CC genotype of rs648438 might be a protective factor for water-drinking-type skeletal fluorosis, especially in male participants.

KEYWORDS:

• Skeletal fluorosis
• single nucleotide polymorphism
• LRP5 rs648438

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data that support the findings of this study are available from the corresponding author, [Yanhui Gao], upon reasonable request.

Ethics approval

The study was proved by the Harbin Medical University, Center for Endemic Disease Control Ethics Committee (HRBMUECDC 20,200,317).

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/09603123.2022.2163989

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China under Grant [U1812403]; The National Natural Science Foundation of China under Grant [82273751]; and The National Natural Science Foundation of China under Grant [82073493].