120
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Reduction of ovarian reserves and activation of necroptosis to in vivo air pollution exposures

, , , , , , , , & show all
Pages 2052-2066 | Received 12 Mar 2023, Accepted 30 Apr 2023, Published online: 19 May 2023
 

ABSTRACT

We investigated the association between air pollution and changes in ovarian follicles, anti-mullerian hormone (AMH) levels, the occurrence of necroptosis cell death by activation of receptor-interacting protein kinase 3 (RIPK3) and, the activation of mixed lineage kinase domain-like (MLKL) proteins. Forty-two female Wistar rats were divided into three groups of 14 each, which were exposed to real-ambient air, filtered air and purified air (control) in two periods of 3 and 5 months. The results showed that the number of ovarian follicles decreased in the group exposed to real-ambient air versus the control group (P < 0.0001). The trend of age-related AMH changes with respect to exposure to air pollutants was affected and its levels decreased after 3 months of exposure. The MLKL increased in the group exposed to the real-ambient air compared to the control group (P = 0.033). Apparently long-term exposure to air pollution can reduce ovarian reserves.

Acknowledgements

The authors acknowledge the Shahid Beheshti University of Medical Sciences for financially supporting this research.

Disclosure statement

There is no actual or potential conflict of interest among the authors.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/09603123.2023.2210109

Data availability statement

The data generated or analyzed during this study are included in this published article and its supplementary information files.

Ethics approval and consent to participate

Ethics code (IR.SBMU.RETECH.REC.1398.701) was approved by the ethics committee of Shahid Beheshti University of Medical Sciences.

Additional information

Funding

This study was funded by Shahid Beheshti University of Medical Sciences, Tehran, Iran (grant number # 21880).

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 371.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.