![Sample our Food Science & Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5936/TOC-Subject-Sample-2021-Food-Science-Technology.jpg"})
Abstract
The aim was to compare postprandial plasma levels of calprotectin, cortisol, triglycerides and zonulin between a control breakfast and a moderately low-carbohydrate test breakfast, given randomly after 10-h fast. Blood samples were collected before and repeatedly after the meal. Plasma calprotectin, cortisol, triglycerides and zonulin were analyzed. The total area under the curve (tAUC) and change in AUC from baseline (dAUC) were calculated. Ratios between the test and control values were calculated to investigate equivalence. Healthy volunteers (8 men and 12 women; 46.0 ± 14.5 years) were included. tAUCs of cortisol and triglycerides did not differ between the breakfasts (p = 0.158 versus p = 0.579). Cortisol dAUCs were decreased and triglyceride dAUCs were increased after both breakfasts, with no differences between the breakfasts (p = 0.933 versus p = 0.277). Calprotectin and zonulin levels were unaffected. The meals were bioequivalent for cortisol, triglycerides and zonulin, but not for calprotectin.
Acknowledgements
We want to acknowledge Igelösa Life Science AB, Lund, whose staff supplied and prepared the breakfasts, and the staff at the Internal Medicine Research Group, Skåne University Hospital, Malmö, for performing the trials. Calprotectin and zonulin were analyzed by Mehrnaz and Shahram Lavasani at ImmuneBiotech AB, Lund Life Science Incubator, Medicon Village, Lund, Sweden.
Disclosure statement
There are no conflicts of interest.
Funding information
This study was supported by grants from Hans-Gabriel and Alice Trolle Wachtmeister’s Foundation for Medical Research, King Gustaf V’s and Queen Victoria Free Maison’s Foundation, Dir Albert Påhlsson’s Foundation, the Development Foundation of Region Skåne, and the Foundation of Skåne University Hospital.