Association between serum cholesterol levels and Alzheimer’s disease in China: a case-control study

Abstract

To examine the association between blood cholesterol concentrations and Alzheimer’s disease (AD) in the Chinese elderly. A case-control study was implemented between November 2011 and November 2017. Elderly patients aged ≥ 55 years with (n = 117) and without AD (control participants; n = 117) were recruited from the Neurology Central Hospital of Tianjin, China. The associations between AD and blood parameters were assessed using multiple binary logistic regression analyses adjusted for multiple covariates. Higher serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels and lower serum high-density lipoprotein cholesterol (HDL-C) levels associated with AD risk in the models adjusted for (1) age, sex and education; and (2) further adjusted for body mass index, smoking status, stroke, hypertension, type 2 diabetes mellitus and heart disease. Increased serum TC and LDL-C levels and lower HDL-C levels were independently associated with the risk of AD.

Keywords:

• Cholesterol
• triglycerides
• high-density lipoproteins
• low-density lipoproteins
• cognitive dysfunction
• dementia
• elderly

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by a grant from the Tianjin Science and Technology Support Program (No. 15ZCZDSY01040), Scientific Program of the Tianjin Education Committee (No. 2016YD20) and National Science Foundation of Tianjin Medical University (No. 2110-2GW034).