Vitamin E intake and paraoxonase 1 (PON1) rs662 genetic polymorphism are associated with colorectal cancer risk in a Korean population

Abstract

Vitamin E and paraoxonase 1 (PON1) are associated with cancer development. However, their interactive effect on colorectal cancer (CRC) risk is inconclusive. We conducted a case–control study including 1,351 CRC patients and 2,670 controls at the Korean National Cancer Centre (KNCC). There was an inverse association between vitamin E intake and CRC risk (odds ratio (OR) = 0.31; 95% confidence interval (CI) = 0.22–0.42). We identified a reduced CRC risk among individuals with CC genotype of PON1 rs662 polymorphism compared with subjects carrying the T allele (OR = 0.74; 95% CI = 0.61–0.90). The highest interaction between vitamin E intake and PON1 rs662 variants was significant for the subjects carrying the CC genotype (p-interaction = 0.014). This study provided further supporting evidence that vitamin E intake is associated with lower odds of CRC. Furthermore, the activity of vitamin E is strengthened among individuals carrying C allele of the PON1 rs662 polymorphism.

Keywords:

• Vitamin E
• paraoxonase 1
• PON1
• colorectal cancer

Author contributions

A.Q.B., A.S., and J.S.K. designed and conducted the research; J.L., J.H.O., D.K.S., and H.J.C. collected the data; A.Q.B. and M.G. analysed the data; A.Q.B. wrote the manuscript draft; and M.G. and J.S.K. revised the manuscript. All authors read and approved the final paper.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the International Cooperation & Education Program [NCCRI•NCCI 52210-52211, 2022] of the National Cancer Centre, Korea, and grants from the National Cancer Centre, Korea [2210990] and the National Research Foundation of Korea [2021R1A2C2008439].