https://orcid.org/0000-0001-9861-4702
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ABSTRACT
Background: MicroRNAs (miRNAs) participate in gene regulation and the control of cancer-related mechanisms such as apoptosis, invasion and differentiation. Single nucleotide polymorphisms (SNP) of the miRNA encoding genes may influence the development of cancer. We hypothesized a link between miR-559 SNP rs58450758 and breast cancer.
Materials & methods: Bioinformatics analyses were performed to predict the miR-559 target genes and the effect of the rs58450758 SNP on the stem-loop structure. A total of 129 breast cancer cases and 153 controls were genotyped using PCR-RFLP.
Results: The recessive genotype (TT) was more common among breast cancer patients (23.3%) than among controls (2%). The non-dominant genotypes (CT+TT) were associated with breast cancer in patients (OR 3.62; 95% CI, 1.95–6.69; p < 0.0001). Bioinformatics analyses suggested that rs58450758 changes miR-559 secondary structure and forms new DICER sites in the pre-miRNA.
Conclusion: The miR-559 rs58450758 variant is linked to breast cancer.
KEYWORDS:
Disclosure statement
No potential conflict of interest was reported by the authors.