Inhibition of Apoptosis in Sheep Monocytes by Brucella melitensis 16M

Abstract

Bishor, V.I., Singh, D.K., Sinha, D.K. and Goswami, T.K. 2004. Inhibition of apoptosis in sheep monocytes by Brucella melitensis 163VI. J. Appl. Anim. Res., 25: 65–68.

Brucella is a facultative intracellular organism of domestic animals and man. The mechanism for its survival is not well understood. The effect of Brucella in modulation of monocytes and neutrophil apoptosis in sheep was analysed. The apoptosis of neutrophils was not affected by the Brucella melitensis 16M (live or killed). However, the live B. melitensis 16M prolonged apoptosis of monocytes/macrophages separated from sheep in vitro.

Keywords:

• Apoptosis
• Brucella melitensis
• macrophage
• monocyte
• neutrophil